Incidence of rare cancers in the city of Sao Paulo, Brazil
Incidence of rare cancers in the city of Sao Paulo, Brazil
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DOI：
10.1177/0300891618821039
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发表时间：
2019-02-01
期刊：
影响因子：
1.9
通讯作者：
Gatta, Gemma
中科院分区：
文献类型：
--
作者：
Bustamante-Teixeira, Maria Teresa;Latorre, Maria do Rosario D. O.;Gatta, Gemma
罕见癌症是临床实践以及流行病学和公共卫生的挑战。关于这一主题的研究很少，仅限于流行病学信息稀缺的病例研究。本研究旨在评估罕见癌症的发病率，并比较罕见和非罕见（常见）癌症的人口统计学、解剖学和组织学特征。方法：发病率数据来自巴西圣保罗基于人群的癌症登记处。罕见肿瘤是RARECARE列表中定义的肿瘤，其中考虑到发生率低于6/100，000/年。结果：在圣保罗，从1997年到2012年，20.4%的肿瘤发病率低于6/10万/年，因此被认为是罕见肿瘤。我们确定了11个实体的发病率大于6/100，000/年（常见肿瘤）和186个实体的发病率低于6/100，000/年（罕见肿瘤）。1997年至2012年期间，圣保罗所有癌症的平均年发病率为每10万人365例，所有罕见肿瘤的发病率为每10万人74.5例。结论：这项研究提出了巴西罕见癌症的负担。预计这将是对这些实体进一步研究的激励，以了解巴西罕见肿瘤的流行病学概况，并提供更有效的诊断和治疗方法。
Introduction: Rare cancers are a challenge for clinical practice as well as for epidemiology and public health. Studies on this subject are few and limited to the study of cases with scarce epidemiologic information. This study aimed to evaluate the incidence of rare cancers and to compare the demographic, anatomic, and histologic characteristics of rare and nonrare (common) cancers. Methods: Incidence data were obtained from the Population-based Cancer Registry of Sao Paulo, Brazil. Rare neoplasms were those defined in the RARECARE list, which takes into account an incidence lower than 6/100,000/year. Results: In Sao Paulo, 20.4% of tumors had an incidence lower than 6/100,000/year from 1997 to 2012, being therefore considered as rare tumors. We identified 11 entities with an incidence greater than 6/100,000/year (common neoplasms) and 186 entities with an incidence lower than 6/100,000/year (rare neoplasms). The mean annual incidence of all cancers was 365 per 100,000 in Sao Paulo between 1997 and 2012, and the incidence of all rare tumors was 74.5 per 100,000. Conclusions: This study presents the burden of rare cancers in Brazil. It is expected to be an incentive for further studies of these entities in order to know the epidemiologic profile of rare tumors in Brazil and to provide a more effective diagnostic and therapeutic approach.