Frontotemporal Dementia
Frontotemporal Dementia
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DOI：
10.1016/j.nc1.2017.01.008
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发表时间：
2017-05-01
影响因子：
2.4
通讯作者：
Miller, Bruce L.
中科院分区：
文献类型：
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作者：
Olney, Nicholas T.;Spina, Salvatore;Miller, Bruce L.
额颞叶痴呆（FTD）自1892年由皮克首次描述以来，在命名和分类方案上经历了许多变化。目前，FTD包括临床障碍，包括行为、语言、执行控制和运动症状的改变。在这里，该术语被用来描述核心的FTD谱系障碍：行为变异型FTD (bvFTD)，非流利/语法变异型原发性进行性失语症（nfvPPA）和语义变异型PPA （svPPA）。讨论的相关FTD疾病包括运动神经元病（FTD- mnd）、进行性核上麻痹综合征（PSP-S）和皮质-基底综合征（CBS）。额颞叶变性（FTLD）一词用于引起额叶和颞叶变性的病理情况。FTD是一种异质性疾病，具有不同的临床表型，与多种神经病理基质相关。
Frontotemporal dementia (FTD) has undergone numerous changes in nomenclature and categorization schemes since it was first described by Pick in 1892. Presently, FTD encompasses clinical disorders that include changes in behavior, language, executive control, and motor symptoms. Here, the term is used to characterize the core FTD spectrum disorders: behavioral variant FTD (bvFTD), nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA). Related FTD disorders discussed include frontotemporal dementia with motor neuron disease (FTD-MND), progressive supranuclear palsy syndrome (PSP-S), and cortico-basal syndrome (CBS). The term frontotemporal lobar degeneration (FTLD) is used for pathologic conditions that cause degeneration of frontal and temporal lobes. FTD is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic substrates.