Lupus anticoagulants, anticardiolipin antibodies, and cerebral ischemia.
Lupus anticoagulants, anticardiolipin antibodies, and cerebral ischemia.
复制标题
狼疮抗凝剂、抗心磷脂抗体和脑缺血。
DOI：
10.1161/01.str.20.2.225
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发表时间：
1989
期刊：
影响因子：
8.3
通讯作者：
Simonian,N
中科院分区：
文献类型：
--
作者：
Kushner,M;Simonian,N
我们研究了23名患有脑缺血的患者，他们也有狼疮抗凝剂（LA）或异常抗心磷脂抗体（ACA）的实验室证据。4名患者患有狼疮或狼疮样疾病，3名患者患有药物诱导的狼疮，16名患者没有明显的胶原血管疾病证据。71%的患者发生了多发性脑缺血事件; 2例患者出现多发性梗死性痴呆。57%的患者存在公认的脑血管疾病危险因素。部分凝血活酶时间延长，只有35%的患者。在21例患者中有15例检测到LA，在12例患者中有10例检测到ACA滴度升高。同时测定LA和ACA是不一致的10例患者中的8个测试。LA和ACA相关的脑缺血通常是复发性的，但脑血管疾病的其他危险因素也经常存在。这些患者的实验室检查结果可能显示出相当大的异质性。
We studied 23 patients suffering cerebral ischemia who also had laboratory evidence of either a lupus anticoagulant (LA) or an abnormal anticardiolipin antibody (ACA). Four patients had lupus or a lupus-like illness, three had drug-induced lupus, and 16 had no overt evidence of collagen-vascular disease. Cerebral ischemic events were multiple in 71% of the patients; two patients presented with multi-infarct dementia. Recognized cerebrovascular disease risk factors were present in 57% of the patients. The partial thromboplastin time was prolonged in only 35% of the patients. An LA was identified in 15 of 21 patients tested, and an elevated ACA titer was identified in 10 of 12 patients tested. Simultaneous assays for LA and ACA were discordant in eight of 10 patients tested. LA- and ACA-associated brain ischemia is often recurrent, but other risk factors for cerebrovascular disease are often present. The laboratory findings in such patients may display considerable heterogeneity.