Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
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DOI：
10.1016/j.celrep.2021.109411
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发表时间：
2021-07-21
期刊：
影响因子：
8.8
通讯作者：
Zhuo, Min
中科院分区：
文献类型：
--
作者：
Li, Xu-Hui;Matsuura, Takanori;Zhuo, Min
催产素是一种神经垂体激素，在行为焦虑和伤害感受中起重要作用。长时程增强的两种主要形式，突触前LTP（pre-LTP）和突触后LTP（post-LTP），已被确定在前扣带皮层（ACC）。前LTP和后LTP有助于慢性疼痛相关的焦虑和行为敏感化。催产素在ACC中的作用尚未研究。在这里，我们发现，催产素到ACC的微量注射减弱神经病理性疼痛动物的伤害性反应和焦虑样行为反应。催产素的应用选择性地阻断前LTP的维持，但不阻断后LTP的维持。此外，催产素增强抑制性传递并兴奋ACC中间神经元。通过对患有神经性疼痛的动物的ACC中含有催产素的投射末梢进行选择性光学刺激，获得了类似的结果。我们的研究结果表明，催产素作用于中枢突触，并通过减少前LTP来减少慢性疼痛引起的焦虑。
Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and post-LTP contribute to chronic-pain-related anxiety and behavioral sensitization. The roles of oxytocin in the ACC have not been studied. Here, we find that microinjections of oxytocin into the ACC attenuate nociceptive responses and anxiety-like behavioral responses in animals with neuropathic pain. Application of oxytocin selectively blocks the maintenance of pre-LTP but not post-LTP. In addition, oxytocin enhances inhibitory transmission and excites ACC interneurons. Similar results are obtained by using selective optical stimulation of oxytocin-containing projecting terminals in the ACC in animals with neuropathic pain. Our results demonstrate that oxytocin acts on central synapses and reduces chronic-pain-induced anxiety by reducing pre-LTP.