Dynamics of Helicobacter pylori colonization in relation to the host response
Dynamics of Helicobacter pylori colonization in relation to the host response
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DOI：
10.1073/pnas.96.15.8359
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发表时间：
1999-07-20
影响因子：
11.1
通讯作者：
Kirschner, D
中科院分区：
文献类型：
--
作者：
Blaser, MJ;Kirschner, D
幽门螺杆菌定植的动力学，从其收购通过发展的稳态检查通过一个数学模型，其中包括主机的反应。该模型包括宿主和微生物变异。的主机响应的个人能力被证明是一个关键的模型参数，导致短暂或持久的殖民化，而该响应的增长率几乎没有影响。竞争菌株的分析表明，每个必须占据一个特定的生态位，否则发生排斥。该模型表明宿主对土著微生物区系的反应存在一个下限，这与目前对H.幽门。平行模型可能有助于理解其他持久的宿主-微生物相互作用。
The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model encompasses both host and microbiological variation. The individual capacity of the host response is shown to be a key model parameter, leading to either transient or persistent colonization, whereas the growth rate of that response has little effect. Analyses of competing strains indicate that each must occupy a specific niche, otherwise exclusion occurs. The model implies that there exists a lower bound on the host response to the indigenous microflora that is consistent with current biological views of H. pylori. Parallel models may be useful in understanding other persistent host-microbial interactions.