Role of gap junctions in CO2 chemoreception and respiratory control
Role of gap junctions in CO2 chemoreception and respiratory control
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DOI：
10.1152/ajplung.00142.2002
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发表时间：
2002-10-01
影响因子：
4.9
通讯作者：
Solomon, IC
中科院分区：
文献类型：
--
作者：
Dean, JB;Ballantyne, D;Solomon, IC
间隙连接由连接蛋白组成，它们被组织成细胞间通道，形成神经元之间的跨膜通路（细胞-细胞偶联），在某些情况下，神经元和神经胶质之间，用于离子和小分子（代谢偶联）和离子电流（电偶联）的交换。通过间隙连接的细胞-细胞偶联已在脑干神经元中被发现，这些神经元在CO2/H+化学接受和呼吸节律发生中起作用；然而，间隙连接在呼吸控制中的确切作用尚未确定。在这里，我们回顾了在体外和体内条件下研究哺乳动物脑干缝隙连接的常用方法，并简要总结了迄今为止在呼吸节律发生和中枢化学接受中支持细胞-细胞偶联作用的解剖学、药理学和电生理学证据。提出了有关间隙连接在呼吸控制中的作用的具体研究问题。
Gap junctions are composed of connexins, which are organized into intercellular channels that form transmembrane pathways between neurons (cell-cell coupling), and in some cases, neurons and glia, for exchange of ions and small molecules (metabolic coupling) and ionic current (electrical coupling). Cell-cell coupling via gap junctions has been identified in brain stem neurons that function in CO2/H+ chemoreception and respiratory rhythmogenesis; however, the exact roles of gap junctions in respiratory control are undetermined. Here we review the methods commonly used to study gap junctions in the mammalian brain stem under in vitro and in vivo conditions and briefly summarize the anatomical, pharmacological, and electrophysiological evidence to date supporting roles for cell-cell coupling in respiratory rhythmogenesis and central chemoreception. Specific research questions related to the role of gap junctions in respiratory control are suggested for future research.