Effects of KW-3902, a novel adenosine A1-receptor antagonist, on cephaloridine-induced acute renal failure in rats.
Effects of KW-3902, a novel adenosine A1-receptor antagonist, on cephaloridine-induced acute renal failure in rats.
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KW-3902（一种新型腺苷 A1 受体拮抗剂）对头孢氯定诱导的大鼠急性肾衰竭的影响。
DOI：
10.1254/jjp.64.9
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Akira Karasawa
中科院分区：
文献类型：
--
作者：
K. Nagashima;H. Kusaka;Kiyoshi Sato;Akira Karasawa
我们研究了KW-3902（8-（去甲金刚烷-3-基）-1，3-二丙基黄嘌呤），一种选择性和有效的腺苷A1受体拮抗剂，对头孢拉啶（CER）诱导的大鼠急性肾功能衰竭（ARF）的可能的肾脏保护作用。以600 mg/kg体重的剂量静脉注射CER诱导ARF。KW-3902剂量高于0.01 mg/kg（p.o.）剂量依赖性地减轻CER诱导的ARF大鼠肌酐清除率的降低和蛋白尿的增加。速尿和三氯噻嗪（中药）增加尿蛋白，血清指标恶化。这些结果表明，KW-3902在与CER联合使用时比速尿和中药具有一定的优势。在CER诱导的ARF大鼠的利尿研究中，KW-3902、呋塞米和TCM引起钠排泄显著增加，而乙酰唑胺无效。这些结果表明，CER诱导的ARF大鼠近端小管功能受损，这与近端小管变性的组织学观察结果雅阁。从KW-3902即使在CER诱导的ARF中也诱导利尿作用的事实，表明KW-3902直接或间接作用于肾脏中的近端小管或其他肾小管部位，导致利尿作用。
We investigated the possible renal protective effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a selective and potent adenosine A1-receptor antagonist, against cephaloridine (CER)-induced acute renal failure (ARF) in rats. ARF was induced by intravenous injection of CER at a dose of 600 mg/kg body weight. KW-3902 at doses higher than 0.01 mg/kg (p.o.) dose-dependently attenuated the decrease of creatinine clearance and the increase of proteinuria in rats with CER-induced ARF. In contrast, furosemide and trichlormethiazide (TCM) increased urinary protein and aggravated the serum parameters. These results suggest that KW-3902 has some advantages over furosemide and TCM when used in combination with CER. In the diuretic study in the rats with established ARF induced by CER, KW-3902, furosemide and TCM caused a significant increase in sodium excretion, whereas acetazolamide was ineffective. These results suggest that the proximal tubule is functionally damaged in rats with CER-induced ARF, in accord with the histological observation demonstrating the degeneration of the proximal tubule. From the fact that KW-3902 induces diuretic action even in CER-induced ARF, it is suggested that KW-3902 acts, directly or indirectly, on the proximal tubule or other tubular sites in the kidney, resulting in the diuretic effect.
茶碱对肌红蛋白尿性急性肾衰竭的保护作用：进一步表征。
影响因子：
2.1
作者：
Bidani,AK;Churchill,PC;Packer,W
通讯作者：
Packer,W