Longitudinal genetic analysis for loneliness in Dutch twins
Longitudinal genetic analysis for loneliness in Dutch twins
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DOI：
10.1375/twin.10.2.267
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发表时间：
2007-04-01
影响因子：
0.9
通讯作者：
Clark, Shaunna
中科院分区：
文献类型：
--
作者：
Boomsma, Dorret I.;Cacioppo, John T.;Clark, Shaunna
在以前的研究中，我们获得的证据表明，孤独的变化有遗传成分。基于成年双胞胎数据，孤独感的遗传力估计值为48%，孤独感被评估为一个序数性状。这些分析是对孤独分数进行平均的，这些分数是在项目（“我感到孤独”和“没有人爱我”）和时间点上进行的。在这篇文章中，我们提出了一个纵向分析的孤独数据评估在5个调查（1991年至2002年）在荷兰双胞胎（N = 8389）的孤独量表的两个独立的项目。根据纵向生长建模，发现仅截距具有非零方差就足够了，而其他效应（线性、二次和三次斜率）具有零方差。对于“我感到孤独”这一项，我们观察到30岁之前的年龄趋势不断增加，然后下降到50岁。截距个体差异的遗传率估计为77%。对于“没人爱我”这一项，没有发现随年龄增长的显著趋势;截距的遗传率估计为70%。
In previous studies we obtained evidence that variation in loneliness has a genetic component. Based on adult twin data, the heritability estimate for loneliness, which was assessed as an ordinal trait, was 48%. These analyses were done on loneliness scores averaged over items ('I feel lonely' and 'Nobody loves me') and over time points. In this article we present a longitudinal analysis of loneliness data assessed in 5 surveys (1991 through 2002) in Dutch twins (N = 8389) for the two separate items of the loneliness scale. From the longitudinal growth modeling it was found sufficient to have non-zero variance for the intercept only, while the other effects (linear, quadratic and cubic slope) had zero variance. For the item 'I feel lonely' we observed an increasing age trend up to age 30, followed by a decline to age 50. Heritability for individual differences in the intercept was estimated at 77%. For the item 'Nobody loves me' no significant trend over age was seen; the heritability of the intercept was estimated at 70%.