Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON).
Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON).
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DOI：
10.1038/sj.bjc.6605459
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发表时间：
2010-01-05
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
在肺癌CT筛查中，参与者通常在基线时有不确定的筛查结果，需要随访CT。在筛查后结果不确定或阴性的受试者中，我们调查了与健康相关的生活质量(HRQOL)是否随着时间的推移而变化，并在短期内在不同组之间存在差异。在Nelson试验中，共有733名参与者收到了四份问卷：T0，随机前；T1，基线筛查前1周；T2，筛查后1天；以及T3，筛查结果后2个月，但在3个月随访CT之前。HRQOL被测量为一般的HRQL(12项简表，SF-12；EuroQol问卷，EQ-5D)，焦虑(斯皮尔伯格状态-特质焦虑问卷，STAI-6)，以及肺癌特有的苦恼(事件量表的影响，IES)。对于分析，使用重复测量的方差分析，并对协变量进行调整。每份问卷的回复率都在88%或更高。SF-12、EQ-5D和STAI-6的得分没有显示出临床相关性随时间的变化。在T3，临床相关的IES分数在不确定的结果后增加，而这些分数在阴性结果后显著下降。在T3时，两个基线结果组之间的IES评分差异显著且与临床相关(P<；0.01)。这项对肺癌筛查计划参与者的纵向研究表明，在短期内，接受不确定结果的人会经历更多的肺癌特有的痛苦，而在基线筛查结果为阴性后，HRQL的变化可能被解释为一种解脱。
In lung cancer CT screening, participants often have an indeterminate screening result at baseline requiring a follow-up CT. In subjects with either an indeterminate or a negative result after screening, we investigated whether health-related quality of life (HRQoL) changed over time and differed between groups in the short term. A total of 733 participants in the NELSON trial received four questionnaires: T0, before randomisation; T1, 1 week before the baseline screening; T2, 1 day after the screening; and T3, 2 months after the screening results but before the 3-month follow-up CT. HRQoL was measured as generic HRQoL (the 12-item Short Form, SF-12; the EuroQol questionnaire, EQ-5D), anxiety (the Spielberger State-Trait Anxiety Inventory, STAI-6), and lung-cancer-specific distress (the Impact of Event Scale, IES). For analyses, repeated-measures analysis of variance was used, adjusted for covariates. Response to each questionnaire was 88% or higher. Scores on SF-12, EQ-5D, and STAI-6 showed no clinically relevant changes over time. At T3, IES scores that were clinically relevant increased after an indeterminate result, whereas these scores showed a significant decrease after a negative result. At T3, differences in IES scores between the two baseline result groups were both significant and clinically relevant (P<0.01). This longitudinal study among participants of a lung cancer screening programme showed that in the short term recipients of an indeterminate result experienced increased lung-cancer-specific distress, whereas the HRQoL changes after a negative baseline screening result may be interpreted as a relief.
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肺癌筛查：前进的方向。
影响因子：
8.8
作者：
Field, J. K.;Duffy, S. W.
通讯作者：
Duffy, S. W.
影响因子：
5.1
作者：
Laaksonen, M;Rahkonen, O;Lahelma, E
通讯作者：
Lahelma, E
影响因子：
2.1
作者：
Essink-Bot, M L;Stouthard, M E;Bonsel, G J
通讯作者：
Bonsel, G J
影响因子：
7.2
作者：
Gandek, B;Ware, JE;Sullivan, M
通讯作者：
Sullivan, M
DOI：
10.1164/rccm.200802-336oc
发表时间：
2008-11-01
影响因子：
24.7
作者：
Wilson, David O.;Weissfeld, Joel L.;Siegfried, Jill M.
通讯作者：
Siegfried, Jill M.