Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study
Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study
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DOI：
10.1093/schbul/sbaa081
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发表时间：
2021-01-01
影响因子：
6.6
通讯作者：
Heckers, Stephan
中科院分区：
文献类型：
--
作者：
Avery, Suzanne N.;Armstrong, Kristan;Heckers, Stephan
背景：关系记忆，即将信息绑定到复杂记忆的能力，在早期精神病中受到中度损害，在慢性精神分裂症中受到严重损害，这表明关系记忆可能在整个病程中恶化。方法：我们检查了 66 名早期精神病患者和 64 名健康对照受试者的关系记忆，其中 59 名患者和 52 名对照受试者在基线和 2 年随访时进行了纵向评估。关系记忆通过两项互补任务进行评估，以测试个体如何学习项目之间的关系（面部场景绑定任务）并对经过训练的关系进行推理（联想推理任务）。结果：与健康对照组相比，早期精神病组在两项任务中都表现出关系记忆受损。早期精神病患者学习项目之间关系的能力仍然受到损害，而对经过训练的关系进行推断的能力有所提高，尽管从未达到健康控制表现的水平。随访时未进展为精神分裂症的早期精神病患者比进展为精神分裂症的患者具有更好的关系记忆。结论：关系性记忆障碍是早期精神病干预的目标，其中一些障碍在未进展为精神分裂症的患者中有所改善且不太严重。
Background: Relational memory, the ability to bind information into complex memories, is moderately impaired in early psychosis and severely impaired in chronic schizophrenia, suggesting relational memory may worsen throughout the course of illness. Methods: We examined relational memory in 66 early psychosis patients and 64 healthy control subjects, with 59 patients and 52 control subjects assessed longitudinally at baseline and 2-year follow-up. Relational memory was assessed with 2 complementary tasks, to test how individuals learn relationships between items (face-scene binding task) and make inferences about trained relationships (associative inference task). Results: The early psychosis group showed impaired relational memory in both tasks relative to the healthy control group. The ability to learn relationships between items remained impaired in early psychosis patients, while the ability to make inferences about trained relationships improved, although never reaching the level of healthy control performance. Early psychosis patients who did not progress to schizophrenia at follow-up had better relational memory than patients who did. Conclusions: Relational memory impairments, some of which improve and are less severe in patients who do not progress to schizophrenia, are a target for intervention in early psychosis.