The role of rhinovirus in allergic airway inflammation.
The role of rhinovirus in allergic airway inflammation.
复制标题
鼻病毒在过敏性气道炎症中的作用。
DOI：
10.1111/j.1398-9995.1995.tb01221.x
复制
发表时间：
1997
影响因子：
1.8
通讯作者：
R. RubiodelBarrio
中科院分区：
文献类型：
--
作者：
N. Jm;J. HernándezGarcía;P. Ja;G. Fj;L. Jd;A. Abellán;R. RubiodelBarrio
流行病学数据表明，病毒感染是儿童急性哮喘症状的最重要触发因素，这种关联在许多成人哮喘患者中持续存在。对实验性感染鼻病毒（RV）的志愿者的研究表明，特应性本身并不容易导致异常严重的症状。相比之下，结合病毒感染和过敏原暴露的实验模型已经确定了病毒诱导的炎症和过敏原诱导的炎症之间的潜在联系。虽然体外研究表明，细胞因子可能是这种关联的一个重要组成部分，它们的作用必须通过实验和/或自然鼻病毒感染后在体内采集下气道液体和组织来验证。虽然人们早就认识到普通感冒是哮喘症状的一个强有力的触发因素，但上呼吸道感染和下呼吸道阻塞增加之间的相关机制仍然不清楚。对有或没有呼吸道过敏的志愿者进行实验性感染，可以直接比较这两组人的普通感冒症状。此外，诸如支气管肺泡灌洗和节段性抗原激发的技术已被用于在急性病毒感染期间直接采集下呼吸道流体和组织。
: Epidemiological data demonstrate that viral infections are the most important trigger for acute asthma symptoms in children, and this association persists in many adults with asthma. Studies on volunteers experimentally infected with rhinoviruses (RV) suggest that atopy alone does not predispose to unusually severe symptoms. In contrast, experimental models combining viral infection and allergen exposure have identified potential links between virus-induced and allergen-induced inflammation. While in vitro studies suggest that cytokines may be an important part of this association, their role must be verified by sampling lower airway fluids and tissues in vivo after experimental and/or natural rhinovirus infections. Although it has long been recognized that the common cold is a potent trigger for symptoms of asthma, the mechanisms underlying the association between upper respiratory infection and increased lower airway obstruction remain obscure. The use of experimental infection of volunteers with or without respiratory allergies has enabled direct comparisons of common cold symptoms in these two groups. Furthermore, techniques such as bronchoalveolar lavage and segmental antigen challenge have been used to directly sample lower airway fluids and tissues during acute viral infection.