The effects of nitrobenzene derivatives on oxygen utilization and radiation response of an in vitro tumor model.
The effects of nitrobenzene derivatives on oxygen utilization and radiation response of an in vitro tumor model.
复制标题
硝基苯衍生物对体外肿瘤模型的氧利用和辐射反应的影响。
作者：
J. Biaglow;R. Durand
测定了几种硝基苯衍生物对多细胞球体氧利用率和辐射响应的影响。在这个系统中，最好的放射增敏剂是硝基甲苯，以前报道是一个贫穷的敏化剂缺氧细胞在单层培养。球状体的致敏作用被解释为由于硝基甲苯对细胞氧利用的直接抑制作用，导致位于中心的细胞的再氧合。缺氧辐射增敏剂二硝基苯甲腈显着刺激氧利用产生立即保护，可能是因为球体的缺氧分数增加。在较高浓度和较长时间暴露于药物后，二硝基苯甲腈确实发生了一些放射增敏作用。由硝基甲苯或二硝基苯甲腈引起的辐射响应的改变与作为氧利用率函数的辐射响应的理论预测相当吻合。第三次缺氧试验...
The effects of several nitrobenzene derivatives on the oxygen utilization and radiation response of multicell spheroids have been determined. In this system, the best radiosensitizer was nitrotoluene, previously reported to be a poor sensitizer of anoxic cells in monolayer cultures. The sensitization of the spheroid is interpreted as due to nitrotoluene's immediate inhibitory effect on cellular oxygen utilization resulting in a reoxygenation of the centrally located cells. The anoxic radiosensitizre dinitrobenzonitrile markedly stimulated oxygen utilization producing an immediate protection, presumably because the hypoxic fraction of the spheroid was increased. Some radiosensitization did occur with dinitrobenzonitrile at higher concentrations and after longer periods of exposure to the drug. The altered radiation response, caused by either nitrotoluene or dinitrobenzonitrile, agreed fairly well with the theoretical prediction of the radiation response as a function of oxygen utilization. A third anoxic s...