Long-term symptom recovery and health-related quality of life in patients with mild-to-moderate-severe community-acquired pneumonia
Long-term symptom recovery and health-related quality of life in patients with mild-to-moderate-severe community-acquired pneumonia
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DOI：
10.1378/chest.130.4.1165
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发表时间：
2006-10-01
期刊：
影响因子：
9.6
通讯作者：
Prins, Jan M.
中科院分区：
文献类型：
--
作者：
el Moussaoui, Rachida;Opmeer, Brent C.;Prins, Jan M.
研究目标：社区获得性肺炎（CAP）患者在症状缓解和健康相关生活质量（HRQL）方面的长期结果尚不清楚。我们的目标是使用经过验证的基于患者的结果测量来确定症状缓解率，并在发作数月后评估 HRQL IS。 参与者：患者是从参加一项随机试验的组中招募的，该试验比较了 CAP 的两个治疗持续时间。 2000 年至 2003 年间，我们纳入了 102 名患有轻度至中重度 CAP 的成年人（肺炎严重程度指数，= 80% 的肺炎前健康水平，不依赖于合并症、年龄或病因。IS 月时的 SF-36 评分在患有合并症的患者的八个维度中的四个方面显着受损，但与无合并症患者的参考人群没有差异病情。结论： 轻至中重度 CAP 患者在 6 个月后即可从肺炎中完全康复。研究发现，超过 28 天出现症状以及 HRQL 的任何损害反映的是年龄和合并症，而不是肺炎本身的持续影响。
Study objectives: The long-term outcomes of patients with community-acquired pneumonia (CAP) in terms of symptom resolution and health-related quality of life (HRQL) is unknown. Our objective was to determine the rate of symptom resolution using validated patient-based outcome measures, and to assess HRQL IS months after the episode.Participants: Patients were recruited from a group enrolled in a randomized trial comparing two durations of treatment for CAP. Between 2000 and 2003, we included 102 adults with a mild-to-moderate-severe CAP (pneumonia severity index, = 80% of the prepneumonia health level did not depend on comorbidity, age, or etiology. SF-36 scores at IS months were significantly impaired in four of the eight dimensions for patients with comorbid illness, but did not differ from the reference population for patients without comorbid illness.Conclusion: Patients with mild-to-moderate-severe CAP recover fully from pneumonia after 6 months. The presence of symptoms beyond 28 days and any impairment in HRQL were found to reflect age and comorbidity rather than the persistent effects of the pneumonia itself.