The mechanical control of nervous system development
The mechanical control of nervous system development
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DOI：
10.1242/dev.079145
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发表时间：
2013-08-01
期刊：
影响因子：
4.6
通讯作者：
Franze, Kristian
中科院分区：
文献类型：
--
作者：
Franze, Kristian
迄今为止，神经系统的发育在很大程度上是在生物化学、分子生物学和遗传学的背景下考虑的。然而，越来越多的证据表明，许多生物系统在分化、生长、增殖、迁移和一般功能过程中做出决策时也会整合机械信息。根据最近的发现，我假设神经系统发育过程中的几个步骤，包括神经祖细胞分化、神经元迁移、轴突延伸和大脑折叠，依赖于甚至由机械线索和力量驱动。
The development of the nervous system has so far, to a large extent, been considered in the context of biochemistry, molecular biology and genetics. However, there is growing evidence that many biological systems also integrate mechanical information when making decisions during differentiation, growth, proliferation, migration and general function. Based on recent findings, I hypothesize that several steps during nervous system development, including neural progenitor cell differentiation, neuronal migration, axon extension and the folding of the brain, rely on or are even driven by mechanical cues and forces.