Brain Tumor Stem Cells
Brain Tumor Stem Cells
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DOI：
10.1203/01.pdr.0000203568.63482.f9
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发表时间：
2006-04
影响因子：
3.6
通讯作者：
I. Nakano;H. Kornblum
中科院分区：
文献类型：
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作者：
I. Nakano;H. Kornblum
癌症是由不同的细胞群组成的，从高度增殖的未成熟细胞到各种细胞系的分化程度更高的细胞。干细胞研究的最新进展使癌症干细胞的存在得以在急性髓系白血病、乳腺癌以及最近的脑肿瘤中得到证实。每一种干细胞都与相应器官中的正常干细胞有一些相似之处。在脑肿瘤中，已从多形性胶质母细胞瘤、髓母细胞瘤和室管膜瘤中鉴定出可能的癌症干细胞。这些肿瘤来源的细胞在克隆条件下自我更新，并分化为神经元样细胞和神经胶质样细胞以及混合表型的异常细胞。肿瘤干细胞，而不是其余的肿瘤细胞，通过移植到免疫缺陷小鼠脑中形成继发性肿瘤。本文就脑肿瘤干细胞与正常神经干细胞之间的细胞和分子关系以及脑肿瘤干细胞可能的临床意义作一综述。
Cancers are composed of heterogeneous cell populations ranging from highly proliferative immature cells to more differentiated cells of various cell lineages. Recent advances in stem cell research have allowed for the demonstration of the existence of cancer stem cells in acute myeloid leukemia, breast cancer, and, most recently, in brain tumors. Each of these has some similarities with the normal stem cells in the corresponding organs. In brain tumors, putative cancer stem cells have been identified from glioblastoma multiforme, medulloblastoma and ependymoma. These tumor-derived cells self-renew under clonal conditions, and differentiate into neuron- and glia-like cells as well as into abnormal cells with mixed phenotypes. The tumor stem cells, but not the rest of tumor cells form secondary tumors by transplantation into immunodeficient mouse brain. In this review, we discuss the cellular and molecular relationships between brain tumor stem cells and normal neural stem cells, and also the possible clinical implications of brain tumor stem cells.