Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
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DOI：
10.3945/ajcn.2008.26205
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发表时间：
2008-12-01
影响因子：
7.1
通讯作者：
Key, Timothy J.
中科院分区：
文献类型：
--
作者：
Allen, Naomi E.;Appleby, Paul N.;Key, Timothy J.
背景资料：一些证据表明，低硒摄入量可能与前列腺癌的风险增加有关。目的：本研究的目的是调查血浆硒浓度与随后的前列腺癌风险之间的关系，并通过疾病的分期和分级以及其他因素来检查这种关系。设计：在欧洲癌症与营养前瞻性调查（EPIC）中对男性进行了一项巢式病例对照研究。在959名前列腺癌患者和1059名对照组中评估了血浆硒浓度与前列腺癌风险之间的关系。结果：总体而言，血浆硒浓度与前列腺癌风险无关;硒浓度最高的五分之一男性与最低的五分之一男性的多变量相对风险为0.96（95% CI：0.70，1.31;趋势P = 0.25）。当按疾病的阶段或级别分析时，血浆硒与风险的相关性没有显著差异。同样，硒与风险的关联没有不同的吸烟状态或血浆α-或γ-生育酚concentration.Conclusion：血浆硒浓度与前列腺癌的风险在这个大队列的欧洲男子。美国临床营养杂志2008; 88：1567-75。
Background: Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer.Objective: The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors.Design: A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls.Results: Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration.Conclusion: Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men. Am J Clin Nutr 2008; 88:1567-75.