First year after head and neck cancer: Quality of life
First year after head and neck cancer: Quality of life
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DOI：
10.1200/jco.1999.17.1.352
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发表时间：
1999-01-01
影响因子：
45.3
通讯作者：
Abemayor, E
中科院分区：
文献类型：
--
作者：
Gritz, ER;Carmack, CL;Abemayor, E
目的：头颈部癌症患者的治疗方案深刻影响了几个生活质量领域。通过横断面分析仪已确定recruitative需求，但是，很少有研究前瞻性地评估生活质量，包括心理社会变量的评估，并确定长期follow-up.Participants和方法的预测因素：本研究通过对105例新诊断的口腔，咽，喉原发性鳞状细胞癌患者进行前瞻性评估，解决了这些局限性。参与者参加了一项更大的随机对照试验，比较了提供者提供的戒烟干预与常规护理建议对照条件。参与者在诊断后和治疗前完成了一系列自我报告措施，并在最初的戒烟建议后1个月和12个月完成了额外的生活质量工具。（P = 0.006）以及饮食、饮食和言语方面;然而，后三个代表持续功能障碍的区域，并且变化在统计学上不显著。尽管有这些改善，但患者报告的某些生活质量领域下降，包括婚姻（P = .002）和性功能（P = .017），以及饮酒增加（P < .001）。12个月时生活质量的预测因子包括治疗类型、心境状态量表的活力子量表和最初戒烟后1个月获得的生活质量评分。结论：结果通过在医疗随访中整合心理和行为干预加强了康复管理的必要性。J Clin Oncol 17：352-360。(C)1999年，美国临床肿瘤学会。
Purpose:Treatment regimens for head and neck cancer patients profoundly affect several quality-of-life domains. Rehabilitative needs have been identified through cross-sectional analyser; however, few studies have prospectively assessed quality of life, included assessment of psychosocial variables, and identified predictors of long-term follow-up.Participants and Methods: The present study addresses these limitations through a prospective assessment of 105 patients with a newly diagnosed first primary squamous cell carcinoma of the oral cavity, pharynx, or larynx. Participants were enrolled onto a larger randomized controlled trial comparing a provider-delivered smoking cessation intervention with a usual-care-advice control condition. Participants completed a battery of self-report measures after diagnosis and before treatment and additional quality-of-life instruments at 1 and 12 months after initial smoking cessation advice.Results: Participants displayed improvements at 12 months in functional status (P = .006) and in the areas of eating, diet, and speech; however, the latter three represent areas of continued dysfunction, and the changes were not statistically significant. Despite these improvements, patients reported a decline in certain quality-of-life domains, including marital (P = .002) and sexual functioning (P = .017), as well as an increase in alcohol use (P < .001). Predictors of quality of life at 12 months included treatment type, the Vigor subscale of the Profile of Mood States instrument, and quality-of-life scores obtained I month after initial smoking cessation advice.Conclusion: Results reinforce the need for rehabilitation management through the integration of psychologic and behavioral interventions in medical follow-up.J Clin Oncol 17:352-360. (C) 1999 by American Society of Clinical Oncology.