Clustering of the Genes for Allantoin Degradation in Saccharomyces cerevisiae
Clustering of the Genes for Allantoin Degradation in Saccharomyces cerevisiae
复制标题
酿酒酵母尿囊素降解基因的聚类
作者：
R. Lawther;E. Riemer;B. Chojnacki;T. Cooper
我们已经证明，尿囊素在酿酒酵母中的降解完全通过尿囊酸、尿素和allophanic酸的中间形成进行。然而，尿囊酸和尿素之间的反应数量仍然不清楚，因为我们无法分离出尿囊酸水解酶的突变缺陷。尿囊素酶（dal1）和尿囊素酶（dal2）的结构基因位于染色体IX上着丝粒的近端，顺序为dal1-dal2-lysl。
We have shown that allantoin degradation in Saccharomyces cerevisiae proceeds exclusively through the intermediate formation of allantoic acid, urea, and allophanic acid. The number of reactions between allantoic acid and urea, however, remains obscure owing to our inability to isolate a mutant defective in ureidoglycolate hydrolase. Structural genes for the enzymes, allantoinase (dal1) and allantoicase (dal2) are located on chromosome IX promixal to the centromere in the order dal1-dal2-lysl.