Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice
Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice
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DOI：
10.1016/j.neurobiolaging.2007.05.018
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Delatour, Benoit
中科院分区：
文献类型：
--
作者：
Dhenain, Marc;El Tayara, Nadine El Tannir;Delatour, Benoit
淀粉样蛋白沉积是阿尔茨海默病的标志之一。最近的研究表明，在模拟阿尔茨海默病的转基因小鼠中，使用体内无造反差剂的MRI，丘脑淀粉样斑块比大脑的其他斑块更容易被检测到。我们的研究评估了APP/PS1、PS1和C57BL/6小鼠大群体中这些丘脑斑块的特征。所有小鼠均有丘脑斑点，但频率和大小不同。因此，APP/PS1小鼠的病变发生率和大小更高。然而，即使在APP/PS1小鼠中，也不是所有老年动物都出现丘脑斑点。在APP/PS1小鼠中，斑点检测与淀粉样斑块内高铁和钙负荷有关，从而反映了该斑块捕获大量矿物质的能力。有趣的是，在丘脑外斑块中也检测到钙和铁，但强度较低。丘脑的低强度病变与斑块周围组织中的铁负荷无关，也与微出血、炎症或神经退行性背景无关。(C) 2007爱思唯尔公司版权所有。
Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these thalamic plaques in it large population of APP/PS1, PS1 and C57BL/6 mice. Thalamic spots were detected in all mice but with different frequency and magnitude. Hence, the prevalence and size of the lesions were higher in APP/PS1 mice. However, even in APP/PS1 mice, thalamic spots did not occur in all the old animals. In APP/PS1 mice, spots detection was related to high iron and calcium load within amyloid plaque and thus reflects the ability of such plaque to capture large amounts of minerals. Interestingly, calcium and iron was also detected in extra-thalamic plaques but with a lower intensity. Hypointense lesions in the thalamus were not associated with the iron load in the tissue surrounding the plaques, nor with micro-hemorrhages, inflammation, or a neurodegenerative context. (C) 2007 Elsevier Inc. All rights reserved.