Copper/Manganese Cocatalyzed Oxidative Coupling of Vinylarenes with Ketones
Copper/Manganese Cocatalyzed Oxidative Coupling of Vinylarenes with Ketones
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铜/锰助催化乙烯基芳烃与酮的氧化偶联
DOI：
10.1021/acs.orglett.5b02116
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发表时间：
2015-09-18
期刊：
影响因子：
5.2
通讯作者：
Li, Yi-He
中科院分区：
文献类型：
--
作者：
Lan, Xing-Wang;Wang, Nai-Xing;Li, Yi-He
使用叔丁基过氧化氢作为自由基引发剂，开发了一种新型铜/锰助催化直接氧化偶联末端乙烯基芳烃与酮，通过 C-C 键形成后的 C(sp(3))-H 键官能化。各种酮与末端乙烯基芳烃发生自由基加成，一步生成相应的1,4-二羰基产物，具有优异的区域选择性和效率。提出了一种可能的反应机理。
A novel copper/manganese cocatalyzed direct oxidative coupling of terminal vinylarenes with ketones via C(sp(3))-H bond functionalization following C-C bond formation has been developed using tert-butyl hydroperoxide as the radical initiator. Various ketones underwent a free-radical addition of terminal vinylarenes to give the corresponding 1,4-dicarbonyl products with excellent regioselectivity and efficiency through one step. A possible reaction mechanism has been proposed.