Perisaccadic Perception of Visual Space in People with Schizophrenia
Perisaccadic Perception of Visual Space in People with Schizophrenia
复制标题
精神分裂症患者视觉空间的周知知觉
DOI：
10.1523/jneurosci.4744-13.2014
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Christopher C. Pack
中科院分区：
文献类型：
--
作者：
Alby Richard;J. Churan;Veronica Whitford;G. O’Driscoll;D. Titone;Christopher C. Pack
随之而来的放电信号存在于许多动物的神经系统中，在这些神经系统中，它们具有与感觉和运动信号整合相关的多种功能。在人类中，一个重要的必然放电信号是由动眼结构产生的，并在每次扫视执行时传递给感觉系统。这一信号被认为是与维持准确的视觉感知有关的一系列目的。通过要求受试者定位在眼跳前后短暂闪现的刺激，可以探索动眼必然放电的特性。这类实验的结果通常会显示出很大的定位误差。在这里，我们利用这些众所周知的心理物理效应来评估精神分裂症患者必然放电信号的潜在功能障碍。在标准的视交叉定位任务中，我们发现，与对照组相比，精神分裂症患者在定位视觉刺激方面表现出更大的错误。误差的模式可以被建模为编码瞬时眼睛位置的过抑制的必然放电信号。这一信号的动态变化预测了患者的症状严重程度，暗示了广泛观察到的精神分裂症行为表现的可能机制基础。
Corollary discharge signals are found in the nervous systems of many animals, where they serve a large variety of functions related to the integration of sensory and motor signals. In humans, an important corollary discharge signal is generated by oculomotor structures and communicated to sensory systems in concert with the execution of each saccade. This signal is thought to serve a number of purposes related to the maintenance of accurate visual perception. The properties of the oculomotor corollary discharge can be probed by asking subjects to localize stimuli that are flashed briefly around the time of a saccade. The results of such experiments typically reveal large errors in localization. Here, we have exploited these well-known psychophysical effects to assess the potential dysfunction of corollary discharge signals in people with schizophrenia. In a standard perisaccadic localization task, we found that, compared with controls, patients with schizophrenia exhibited larger errors in localizing visual stimuli. The pattern of errors could be modeled as an overdamped corollary discharge signal that encodes instantaneous eye position. The dynamics of this signal predicted symptom severity among patients, suggesting a possible mechanistic basis for widely observed behavioral manifestations of schizophrenia.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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