Strontium incorporation to optimize the antibacterial and biological characteristics of silver-substituted hydroxyapatite coating
Strontium incorporation to optimize the antibacterial and biological characteristics of silver-substituted hydroxyapatite coating
复制标题
掺入锶优化银取代羟基磷灰石涂层的抗菌和生物特性
DOI：
10.1016/j.msec.2015.08.061
复制
发表时间：
2016-01-01
影响因子：
7.9
通讯作者：
Yang, Xianjin
中科院分区：
文献类型：
--
作者：
Geng, Zhen;Cui, Zhenduo;Yang, Xianjin
Infection in primary total joint prostheses is attracting considerable attention. In this study, silver (Ag) was incorporated into hydroxyapatite (HA) using a hydrothermal method in order to improve its antimicrobial properties. Strontium (Sr) was added as a second binary element to improve the biocompatibility. The substituted HA samples were fixed on titanium (Ti) substrates by dopamine-assisted immobilization in order to evaluate their antibacterial and biological properties. The results showed that Ag and Sr were successfully incorporated into HA without affecting their crystallinity. Further, the antibacterial tests showed that all the Ag-substituted samples had good anti-bacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Despite their good antibacterial ability, the Ag-substituted samples showed evidence of cytotoxicity on MG63 cells, characterized by low cell density and poor spreadability. The addition of Sr to the Ag-substituted samples considerably reduced the cytotoxicity of Ag. Although the viability of the cells grown on the surfaces of co-substituted HA was not as high as that of the cells grown on the HA surfaces, it is believed that excellent antibacterial properties and good biological activity can be achieved by balancing the dosage of Sr and Ag. (C) 2015 Elsevier B.V. All rights reserved.
