Influence of fish oil or folate supplementation on the time course of plasma redox markers during pregnancy
Influence of fish oil or folate supplementation on the time course of plasma redox markers during pregnancy
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DOI：
10.1017/s0007114509993746
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发表时间：
2010-06-14
影响因子：
3.6
通讯作者：
Koletzko, Berthold
中科院分区：
文献类型：
--
作者：
Franke, Corinna;Demmelmair, Hans;Koletzko, Berthold
母亲补充长链多不饱和脂肪酸，以改善婴儿的神经发育，可能会导致额外的氧化应激增加。年龄在18-41岁之间的孕妇被随机分为四个补充组。从第22周开始，他们接受含有改性鱼油（n 69），5-甲基-四氢叶酸（n 65），两者（n 64）或安慰剂（n 72）的补充剂。在第20周和第30周以及分娩时测定血浆Troox当量抗氧化能力（TEAC）、α-生育酚、视黄醇、β-胡萝卜素、游离巯基、尿酸和硫代巴比妥酸反应物质（TBARS）的浓度。所研究的抗氧化剂在四个补充组之间没有显着差异。在第30周，发现鱼油组（0-80（SEM 0.04）μ mol/l）的血浆TBARS水平显著高于叶酸组（0-67（SEM 0-03）μ mol/l：P=0.024）和对照组（0.69（SEM 0.04）μ mol/l; P=0.01）。浓度的视网膜和游离巯基在怀孕期间下降，而尿酸增加和β-胡萝卜素以及TEAC显示只有轻微的变化。在怀孕后半期补充鱼油似乎不会降低抗氧化状态。第30周时TBARS水平升高可能表明此时血浆中氧化应激水平升高。
Maternal supplementation with long-chain PUFA, to improve infant neurological development, might cause additional increase of oxidative stress. Pregnant women aged 18-41 years were randomised into one of four supplementation groups. From week 22 on, they received supplements containing either modified fish oil (n 69), 5-methyl-tetrahydro-folate (n 65), both (n 64), or placebo (n 72). Plasma Trolox-equivalent antioxidative capacity (TEAC), concentrations of alpha-tocopherol, retinol, beta-carotene, free thiol groups, uric acid and thiobarbituric acid-reactive substances (TBARS) were determined at weeks 20 and 30 and at delivery. The studied antioxidants showed no significant differences between the four supplementation groups. At week 30 plasma TBARS levels were found to be significantly higher in the fish oil group (0-80 (SEM 0.04) mu mol/l) than in the folate (0-67 (SEM 0-03) mu mol/l: P=0.024) and control (0.69 (SEM 0.04) mu mol/l; P=0.01) groups. Concentrations of retinal and free thiol groups decreased during pregnancy, whereas uric acid increased and beta-carotene as well as TEAC showed only minor changes. Fish oil supplementation during the second half of pregnancy appears not to decrease antioxidant status. The increased TBARS levels at week 30 may indicate a period of increased oxidative stress in plasma at this time.