Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life
Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life
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DOI：
10.1111/j.1471-0528.2008.01822.x
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Roseboom, T. J.
中科院分区：
文献类型：
--
作者：
Painter, R. C.;Osmond, C.;Roseboom, T. J.
目的母亲妊娠期营养不良与子代代谢和心血管疾病的增加有关。我们调查了这些影响是否会在后代中持续存在。设计历史队列研究。在诊所、家访或电话中进行采访。人口1943年11月至1947年2月期间出生于阿姆斯特丹威廉敏娜·加斯图伊斯（Wilhelmina Gasthuis）的男性和女性。方法我们采访了1944-45年荷兰饥荒前后出生的队列成员（F1），主要观察指标为出生体重、出生身长、体重指数和出生后健康状况（如F1所报告的）855名参与队列成员的后代（F2），结果F1代宫内饥饿暴露对F2代无影响（n = 1496）出生体重，但是，在饥饿暴露的F1妇女的后代中，F2出生身长降低（-0.6 cm，F2性别和胎次调整后的P = 0.01），F2体重指数增加（+1.2 kg/m3，F2性别和胎次调整后的P = 0.001）。在调整可能的混杂因素后，该关联保持不变。在子宫内暴露于饥荒的F1妇女的后代也有健康状况不佳的1.8（95%CI 1.1-2.7）倍，更频繁地在以后的生活中（由于各种原因）比F1 unexposed women.Conclusions我们没有发现跨代的影响，产前暴露于饥荒的出生体重，也没有心血管和代谢疾病的发病率。然而，F1宫内饥饿暴露与F2新生儿肥胖增加和晚年健康状况不佳有关。我们的研究结果可能意味着，在宫内饥饿暴露后慢性疾病的增加不仅限于F1代，但在F2代仍然存在。
Objective Maternal undernutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. We investigated whether these effects may persist in subsequent generations.Design Historical cohort study.Setting Interview during a clinic or home visit or by telephone.Population Men and women born in the Wilhelmina Gasthuis in Amsterdam between November 1943 and February 1947.Methods We interviewed cohort members (F1) born around the time of the 1944-45 Dutch famine, who were exposed or unexposed to famine in utero, about their offspring (F2).Main outcome measures Birthweight, birth length, ponderal index and health in later life (as reported by F1) of the offspring (F2) of 855 participating cohort members, according to F1 famine exposure in utero.Results F1 famine exposure in utero did not affect F2 (n = 1496) birthweight, but, among the offspring of famine-exposed F1 women, F2 birth length was decreased (-0.6 cm, P adjusted for F2 gender and birth order = 0.01) and F2 ponderal index was increased (+1.2 kg/m(3), P adjusted for F2 gender and birth order = 0.001). The association remained unaltered after adjusting for possible confounders. The offspring of F1 women who were exposed to famine in utero also had poor health 1.8 (95% CI 1.1-2.7) times more frequently in later life (due to miscellaneous causes) than that of F1 unexposed women.Conclusions We did not find transgenerational effects of prenatal exposure to famine on birthweight nor on cardiovascular and metabolic disease rates. F1 famine exposure in utero was, however, associated with increased F2 neonatal adiposity and poor health in later life. Our findings may imply that the increase in chronic disease after famine exposure in utero is not limited to the F1 generation but persists in the F2 generation.