Systematic analysis of esophageal pressure topography in high-resolution manometry of 68 normal volunteers
Systematic analysis of esophageal pressure topography in high-resolution manometry of 68 normal volunteers
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DOI：
10.1111/dote.12027
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发表时间：
2013-09-01
影响因子：
2.6
通讯作者：
Peters, J. H.
中科院分区：
文献类型：
--
作者：
Niebisch, S.;Wilshire, C. L.;Peters, J. H.
高分辨率测压（HRM）的引入是食管诊断的一个重大进步。然而，目前的标准值是基于一组已公布的参考值，在过去几年中增加了多个新的指标。我们的目标是提供第二组正常值，并包括2012年芝加哥分类建议的所有当前指标。68例无前肠症状或既往手术史的受试者（中位年龄25.5岁，范围为20-58岁，53%为女性）通过既定标准化方案接受食管动力评估。计算了食管-胃交界处（EGJ）特征（静息、舒张、团内压和长度）以及食管体强度（多个水平的收缩幅度、远端收缩积分、舒张完整性）和波传播（收缩前速度、远端潜伏期）的标准阈值。总的来说，我们的研究结果与先前描述的来自西北大学75名对照受试者的指标惊人相似。这表明人力资源管理的可重复性很高。
The introduction of high-resolution manometry (HRM) has been a significant advance in esophageal diagnostics. Normative values however are currently based upon a single set of published reference values, and multiple new metrics have been added over the past several years. Our goal was to provide a second set of normal-values' and to include all current metrics suggested by the 2012 Chicago classification. Sixty-eight subjects without foregut symptoms or previous surgery (median age 25.5 years, ranging from 20-58 years, 53% female) underwent esophageal motility assessment via an established standardized protocol. Normative thresholds were calculated for esophago-gastric junction (EGJ) characteristics (resting, relaxation, intrabolus pressure, and lengths) as well as for esophageal body strength (contraction amplitudes at multiple levels, distal contractile integral, integrity of peristalsis) and wave propagation (contractile front velocity, distal latency). Overall, our findings where strikingly similar to the previously described metrics derived from 75 control subjects of the Northwestern group. This suggests a high degree of reproducibility of HRM.