Neuroanatomic overlap of working memory and spatial attention networks: A functional MRI comparison within subjects
Neuroanatomic overlap of working memory and spatial attention networks: A functional MRI comparison within subjects
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DOI：
10.1006/nimg.1999.0503
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发表时间：
1999-12-01
期刊：
影响因子：
5.7
通讯作者：
Mesulam, MM
中科院分区：
文献类型：
--
作者：
LaBar, KS;Gitelman, DR;Mesulam, MM
额叶和后顶叶激活已在工作记忆和视觉空间注意的许多研究中报道。为了直接比较这两种认知功能所涉及的大脑区域，同一组受试者在接受功能性MRI（fMRI）时连续参与工作记忆和空间注意的任务。工作记忆任务要求受试者在干扰物的背景下保持对中央凹显示的字母的在线表示。空间注意任务要求受试者对中央呈现的方向性线索进行隐蔽性的视觉注意转移。空间注意任务不需要工作记忆，工作记忆任务不需要内隐空间注意。在MRI扫描仪外使用红外眼电描记术确认受试者保持中心注视的能力。根据认知联合分析，这两个任务共同的激活集包括顶内沟，腹侧中央前沟，辅助运动区，额叶眼区，丘脑，小脑，左颞叶新皮层和右颞叶。双减分析产生了额外的激活归因于言语工作记忆的前运动皮层，左下前额叶皮层，右下顶叶小叶，楔前叶，和右小脑。归因于隐蔽空间注意的其他激活包括枕颞交界处和纹外皮质。在同一组受试者中使用两种不同的任务，使我们能够提供一个明确的证据，即空间注意力和工作记忆的神经网络在几个额顶叶部位相交。这些发现支持了主要认知域由部分重叠的大规模神经网络表示的观点。这种重叠的存在也表明，空间注意和工作记忆有着共同的认知特征，这些特征与注意资源的动态转移有关。(C)北京：科学出版社.
Frontal and posterior parietal activations have been reported in numerous studies of working memory and visuospatial attention. To directly compare the brain regions engaged by these two cognitive functions, the same set of subjects consecutively participated in tasks of working memory and spatial attention while undergoing functional MRI (fMRI). The working memory task required the subject to maintain an on-line representation of foveally displayed letters against a background of distracters. The spatial attention task required the subject to shift visual attention covertly in response to a centrally presented directional cue. The spatial attention task had no working memory requirement, and the working memory task had no covert spatial attention requirement. subjects' ability to maintain central fixation was confirmed outside the MRI scanner using infrared oculography. According to cognitive conjunction analysis, the set of activations common to both tasks included the intraparietal sulcus, ventral precentral sulcus, supplementary motor area, frontal eye fields, thalamus, cerebellum, left temporal neocortex, and right insula. Double-subtraction analyses yielded additional activations attributable to verbal working memory in premotor cortex, left inferior prefrontal cortex, right inferior parietal lobule, precuneus, and right cerebellum. Additional activations attributable to covert spatial attention included the occipitotemporal junction and extrastriate cortex. The use of two different tasks in the same set of subjects allowed us to provide an unequivocal demonstration that the neural networks subserving spatial attention and working memory intersect at several frontoparietal sites. These findings support the view that major cognitive domains are represented by partially overlapping large-scale neural networks. The presence of this overlap also suggests that spatial attention and working memory share common cognitive features related to the dynamic shifting of attentional resources. (C) 1999 Academic Press.