Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N2a cells
Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N2a cells
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DOI：
10.1016/j.molbrainres.2005.09.006
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发表时间：
2005-12-14
期刊：
影响因子：
--
通讯作者：
Kang, SJ
中科院分区：
文献类型：
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作者：
Kang, KL;Oh, YK;Kang, SJ
黄芩是一种中草药，被用来治疗伴随炎症和氧化应激的疾病。在本研究中，我们研究了黄芩提取物在急性乙醇暴露于N(2)a神经母细胞瘤中的作用。黄芩提取物能有效抑制乙醇诱导的细胞凋亡和caspase-3/-7的激活。乙醇诱导caspase-11的表达，caspase-11被认为是病理性细胞凋亡和炎症反应的双重调节因子。黄芩提取物预处理可抑制乙醇诱导的caspase-11表达。此外，乙醇处理后，caspase-11-/-小鼠胚胎成纤维细胞的caspase-3/-7活化和细胞凋亡明显受到抑制。上述结果提示，caspase-11在乙醇诱导的细胞凋亡中具有调控作用，抑制caspase-11可能是黄芩发挥细胞保护作用的机制之一。(c) 2005 Elsevier B.V.版权所有
Scutellariae radix is a Chinese herbal medicine that has been used to treat disease conditions accompanying inflammation and oxidative stress. In the Present study we examined the effect of Scutellariae radix extracts during acute ethanol exposure in N(2)a neuroblastoma. The Scutellariae radix extracts effectively inhibited ethanol-induced apoptosis and caspase-3/-7 activation. Ethanol induced the expression of caspase-11 that has been known as a dual regulator of pathological apoptosis and inflammatory response. The ethanol-induced caspase-11 expression was Suppressed by pretreatment of the Scutellariae radix extracts. Furthermore, the activation of caspase-3/-7 and apoptosis were significantly inhibited in caspase-11-/- mouse embryonic fibroblasts following ethanol treatment. These results Suggest that caspase-11 has a regulatory role in ethanol-induced apoptosis, and the suppression of caspase-11 may be a mechanism by which Scutellariae radix exerts its cytoprotective effect. (c) 2005 Elsevier B.V. All rights reserved.