Progesterone and 3α,5α-THP enhance sexual receptivity in mice
Progesterone and 3α,5α-THP enhance sexual receptivity in mice
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DOI：
10.1037/0735-7044.115.5.1118
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发表时间：
2001-10-01
影响因子：
1.9
通讯作者：
Vongher, JM
中科院分区：
文献类型：
--
作者：
Frye, CA;Vongher, JM
研究了孕酮（P）及其代谢产物对小鼠性感受性（脊柱前凸）的影响。产生正常循环浓度的β和5 α-葡聚糖-3 α-醇-20-酮（3 α，5 α-THP）的β剂量增强了切除卵巢、有性经验的C57 BL/6 J（C57）、+/+ C57 BL/6 J × 129 SvEv（C57 × 129）和-/-C57 BL/6 J × 129 SvEv（PRKO）小鼠的脊柱前凸.只有C57和C57 × 129小鼠下丘脑中的孕酮受体（PR）免疫反应性（PR-IR）增加。RU38486. PR拮抗剂，减弱C57和C57 X 129的脊柱前凸，但不是PRKO。小鼠：epostane，一种雌激素生物合成抑制剂，减少血浆孕激素;和非那肽。一种磷代谢抑制剂。降低血浆3 α，5 α-THP和减弱所有小鼠的脊柱前凸。对于性幼稚小鼠，初次性经验时脊柱前凸较大对应于血浆和中枢孕激素浓度较高以及GABA（A）激动剂蝇蕈醇中枢结合增加。与在初次交配时脊柱前凸较低的小鼠中观察到的相比。因此，小鼠中的P-易化感受性涉及P和3 α，5 α-THP及其对PR和GABA（A）受体的作用。
Progesterone (P) and its metabolites' effects on sexual receptivity (lordosis) of mice was examined. P dosages that produced normal circulating concentrations of P and 5 alpha -pregnan-3 alpha -ol-20-one (3 alpha ,5 alpha -THP) enhanced lordosis of ovariectomized, sexually experienced C57BL/6J (C57), +/+ C57BL/6J X 129SvEv (C57 X 129), and -/- C57BL/6J X 129SvEv (PRKO) mice. Only C57 and C57 X 129 mice had increases in progestin receptor (PR)-immunoreactivity (PR-IR) in the hypothalamus. RU38486. a PR antagonist, attenuated lordosis of C57 and C57 X 129, but not PRKO. mice: epostane, a progestin biosynthesis inhibitor, reduced plasma progestins; and finasteride. a P metabolism inhibitor. reduced plasma 3 alpha ,5 alpha -THP and attenuated lordosis of all mice. For sexually naive mice, greater lordosis on initial sexual experience corresponded to greater concentrations of plasma and central progestins and increased central binding of a GABA(A) agonist, muscimol. compared with that seen in mice with lower lordosis on initial mating. Thus, P-facilitated receptivity in mice involves P and 3 alpha ,5 alpha -THP and their actions at PRs and GABA(A) receptors.