Click Chemistry-Mediated Nanosensors for Biochemical Assays.
Click Chemistry-Mediated Nanosensors for Biochemical Assays.
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用于生化测定的点击化学介导的纳米传感器
DOI：
10.7150/thno.14856
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发表时间：
2016
期刊：
影响因子：
12.4
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Chen Y;Xianyu Y;Wu J;Yin B;Jiang X
Click化学与功能纳米颗粒的结合在生化分析中引起了越来越多的关注，因为它们有望开发具有有效信号转换/放大和直接信号读出的生物传感器，用于临床诊断分析。本文综述了Cu (I)催化叠氮化物和炔的1,3 -偶极环加成（CuAAC）介导的纳米传感器在生化检测方面的最新进展，以及基于click化学的纳米探针功能化的研究进展。纳米探针包括金纳米粒子、量子点、磁性纳米粒子和碳纳米材料。我们讨论了点击化学介导的纳米传感器用于生化分析的优势，并对点击化学介导的临床诊断和其他生物医学应用方法的发展提出了展望。
Click chemistry combined with functional nanoparticles have drawn increasing attention in biochemical assays because they are promising in developing biosensors with effective signal transformation/amplification and straightforward signal readout for clinical diagnostic assays. In this review, we focus on the latest advances of biochemical assays based on Cu (I)-catalyzed 1, 3-dipolar cycloaddition of azides and alkynes (CuAAC)-mediated nanosensors, as well as the functionalization of nanoprobes based on click chemistry. Nanoprobes including gold nanoparticles, quantum dots, magnetic nanoparticles and carbon nanomaterials are covered. We discuss the advantages of click chemistry-mediated nanosensors for biochemical assays, and give perspectives on the development of click chemistry-mediated approaches for clinical diagnosis and other biomedical applications.