Absorptive hyperoxaluria: a new clinical entity--successful treatment with hydrochlorothiazide.
Absorptive hyperoxaluria: a new clinical entity--successful treatment with hydrochlorothiazide.
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吸收性高草酸尿症：一种新的临床实体——氢氯噻嗪的成功治疗。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
M. Cohanim
中科院分区：
文献类型：
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作者：
E. Yendt;M. Cohanim
本报告描述了对一名患有高草酸尿症和草酸钙肾结石的 13 岁女孩进行的 11 年研究，该女孩没有原发性高草酸尿症或继发性高草酸尿症的任何公认原因。该患者还存在钙和镁的尿排泄增加以及膳食钙和镁的吸收过度。有人认为，高草酸尿症是由于膳食钙吸收过多而继发的膳食草酸盐吸收过多所致。此前尚未报道过膳食镁的过度吸收和尿镁排泄增加。在长期噻嗪类治疗期间，结石形成停止，尿草酸排泄逐渐降至正常，但当用正磷酸盐治疗替代氢氯噻嗪时，高草酸尿症复发。这是首次报道患有明显高草酸尿症的患者在噻嗪类药物治疗期间尿草酸盐排泄正常化。
This report describes studies performed over an 11 year period in a 13 year old girl with hyperoxaluria and calcium oxalate nephrolithiasis who did not have primary hyperoxaluria or any of the recognized causes of secondary hyperoxaluria. The patient also had increased urinary excretion of calcium and magnesium and hyperabsorption of dietary calcium and magnesium. It is suggested that the hyperoxaluria resulted from hyperabsorption of dietary oxalate secondary to hyperabsorption of dietary calcium. Hyperabsorption of dietary magnesium and increased urinary magnesium excretion have not previously been reported in this context. Stone formation ceased and urinary oxalate excretion gradually fell to normal during long term thiazide therapy but hyperoxaluria recurred when orthophosphate therapy was substituted for the hydrochlorothiazide. This is the first report of normalization of urine oxalate excretion during thiazide therapy in a patient with frank hyperoxaluria.