LYMPHOCYTE EMPERIPOLESIS IN HUMAN GLIAL-CELLS
LYMPHOCYTE EMPERIPOLESIS IN HUMAN GLIAL-CELLS
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DOI：
10.3109/15419069309097256
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发表时间：
1993-01-01
期刊：
影响因子：
--
通讯作者：
NATH, A
中科院分区：
文献类型：
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作者：
FURER, M;HARTLOPER, V;NATH, A
在多发性硬化斑块和一些脑肿瘤中，已经观察到星形胶质细胞在其细胞质中含有完整的、有活力的淋巴细胞（Empipolesis）。本研究对培养的神经胶质细胞的粘附、吞噬和移行特性进行了研究。人胎儿和成人星形胶质细胞参与淋巴细胞的粘附和吞噬。Emperipolesis，而不是粘附，是温度和阳离子依赖性。CD 8和MHC-I类抗原在帝国主义中起作用。淋巴细胞通常在星形胶质细胞的细胞质内保持活力，但偶尔会发生溶解或导致星形胶质细胞中间丝的破坏。自噬现象不同于吞噬作用，因为小胶质细胞表现出突出的吞噬特性，但不参与自噬。相反，星形胶质细胞是有效的帝国，很少表现出吞噬功能。
Astrocytes have been observed to contain intact, viable lymphocytes within their cytoplasm (emperipolesis) in multiple sclerosis plaques and some brain tumors. This study characterizes the adhesive, emperipoletic and phagocytic Properties of glial cells in culture. Human fetal and adult astrocytes engaged in adhesion and emperipolesis of lymphocytes. Emperipolesis, and not adhesion, was temperature- and cation-dependent. The CD8 and MHC Class I antigens played a role in emperipolesis. Lymphocytes most often remained viable within the cytoplasm of astrocytes but occasionally underwent lysis or caused disruption of the astrocyte intermediate filaments. The phenomenon of emperipolesis is distinct from phagocytosis, since microglia showed prominent phagocytic properties but did not engage in emperipolesis. Conversely, astrocytes were efficient emperipolites and rarely demonstrated phagocytic properties.