Dementia Behavior Disturbance Scale
Dementia Behavior Disturbance Scale
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痴呆症行为障碍量表
DOI：
10.1017/s1041610297003566
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发表时间：
1997
影响因子：
7
通讯作者：
R. Becker
中科院分区：
文献类型：
--
作者：
Serge Gauthier;Mona Baumgarten;R. Becker
在临床实践中，痴呆患者的行为障碍有助于确定疾病的严重程度和支持护理的需要。在阿尔茨海默病患者中，行为症状的早期出现与疾病进展更快有关。直到最近，制药公司对开发治疗行为障碍的药物几乎没有兴趣，因为美国食品和药物管理局在1990年11月8日的"抗痴呆药物临床评价指南"中认为，作用于与阿尔茨海默病相关的非认知症状的药物将是"假特异性的"（即，不针对阿尔茨海默病的核心认知领域）。因此，很少有专门开发的测量量表来评估阿尔茨海默病患者在3至6个月的时间范围内的功能自主性和行为，这是双盲安慰剂对照研究的典型长度。许多现有的量表包括相关的认知，功能自主性，躯体症状和精神问题的异质性项目。痴呆症行为障碍（DBD）量表是在20世纪80年代后期开发的，当时行为症状在痴呆症中的重要性越来越被认识到。最近的抗痴呆药物开发的协调努力进一步强调了痴呆症非认知症状的临床重要性。
In clinical practice, the behavioral disturbances seen in patients with dementia are helpful in determining disease severity and the need for support care. In patients with Alzheimer's disease, the early appearance of behavioral symptoms is associated with faster disease progression. Until recently, pharmaceutical companies have had little interest in developing drugs to treat behavioral disturbances, because the U.S. Food and Drug Administration, in the “Guidelines for the Clinical Evaluation of Antidementia Drugs” dated November 8, 1990, held that drugs acting on noncognitive symptoms associated with Alzheimer's disease would be “pseudospecific” (i.e., not targeted to the core cognitive domains of Alzheimer's disease). As a result, few measurement scales were specifically developed to assess functional autonomy and behavior in patients with Alzheimer's disease within time frames of 3 to 6 months, the typical length of double-blind, placebo-controlled studies. Many of the existing scales included heterogeneous items relevant to cognition, functional autonomy, somatic symptoms, and psychiatric problems. The Dementia Behavior Disturbance (DBD) scale was developed in the late 1980s, a time when the importance of behavioral symptoms in dementia was increasingly being recognized. Recent harmonization efforts for the development of antidementia drugs have further emphasized the clinical importance of noncognitive symptoms in dementia.