Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia.
Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia.
复制标题
猴子的内侧颞叶损伤会损害对人类健忘症敏感的各种任务的记忆。
DOI：
10.1037//0735-7044.99.1.22
复制
发表时间：
1985
影响因子：
1.9
通讯作者：
Squire,LR
中科院分区：
文献类型：
--
作者：
Zola-Morgan,S;Squire,LR
猴子的海马和杏仁核的联合双边病变受损的四个不同的记忆测试（延迟保留的对象歧视，同时歧视，延迟响应，和延迟不匹配的样品）。由于涉及延迟和分心的测试被认为对人类健忘症特别敏感，在三个任务中，训练和测试试验之间的延迟间隔相对较长，在两个任务中，在延迟间隔期间引入分心。损伤的严重程度随着延迟时间的延长而增加，注意力分散明显增加了记忆损伤。对于一个任务，在两个场合（延迟不匹配的样本），减值的严重程度是不变的一段时间为1.5年。与以前的研究结果，技能学习是未受损的相同的操作猴子，本研究的结果加强了这样的结论，内侧颞叶病变的猴子构成了人类健忘症的动物模型。此外，这里使用的四个任务似乎构成了一个敏感和适当的电池，可用于在猴子的记忆功能的神经解剖学的其他研究。
Monkeys with conjoint bilateral lesions of the hippocampus and amygdala were impaired on four different tests of memory (delayed retention of object discriminations, concurrent discrimination, delayed response, and delayed nonmatching to sample). Because tests involving delays and distractions are known to be especially sensitive to human amnesia, in three of the tasks relatively long delay intervals between training and test trials were used, and in two tasks distraction was introduced during the delay intervals. The severity of the impairment increased with the length of the delay, and distraction markedly increased the memory impairment. For one task given on two occasions (delayed nonmatching to sample), the severity of the impairment was unchanged over a period of 1.5 years. Taken together with previous findings that skill learning is unimpaired in the same operated monkeys, the results of the present study strengthen the conclusion that monkeys with medial temporal lesions constitute an animal model of human amnesia. In addition, the four tasks used here appear to constitute a sensitive and appropriate battery that could be used in other studies of the neuroanatomy of memory functions in the monkey.