Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients
Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients
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DOI：
10.1093/cid/ciaa1165
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发表时间：
2021-11-01
影响因子：
11.8
通讯作者：
Deffert, Christine
中科院分区：
文献类型：
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作者：
Bellon, Mathilde;Schweblin, Cecilia;Deffert, Christine
本研究分析31例新型冠状病毒病（COVID-19）合并神经系统并发症患者脑脊液特征。我们在脑脊液中没有观察到严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) RNA，也没有观察到鞘内免疫球蛋白G （IgG）的合成，但确实观察到血脑屏障破坏的迹象。这些结果可能为更好地理解SARS-CoV-2相关的神经发病机制提供基础。
This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.