Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw.
Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw.
复制标题
与双磷酸盐相关的颌骨坏死相关的假性上皮瘤样增生。
作者：
J. Zustin;D. Reske;Tomislav A. Zrnc;M. Heiland;H. Scheuer;Alexandre T. Assaf;R. Friedrich
双膦酸盐相关性颌骨骨坏死（BRONJ）是双膦酸盐全身治疗的一种特征明确的口腔并发症。在一些病变中观察到假上皮瘤样增生。由于podoplanin表达与口腔粘膜的恶性病变有关，我们的目的是研究podoplanin在假上皮瘤样增生中的表达。我们分析了档案石蜡和塑料包埋标本BRONJ使用常规和免疫组化（AE 1/AE 3，D2-40）染色方法。17例BRONJ中11例表现为假上皮瘤样增生。所有这些病例均为AE 1/AE 3阳性，假上皮瘤样增生显示对podoplanin的强基底和副基底反应。BRONJ标本中假上皮瘤样增生中的podoplanin表达不应被视为恶性肿瘤的标志。我们讨论了目前和未来可能的作用，外科病理学家在诊断形态学变化与发展和治疗的BRONJ病变。
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-characterized oral complication of systemic therapy with bisphosphonates. Pseudoepitheliomatous hyperplasia was observed in some of the lesions. Because podoplanin expression has been linked to malignant lesions of the oral mucosa, we aimed to investigate podoplanin expression in the pseudoepitheliomatous hyperplasia. We analyzed archival paraffin- and plastic-embedded specimens from BRONJ using both conventional and immunohistochemical (AE1/AE3, D2-40) staining methods. Eleven out of seventeen BRONJ cases showed pseudoepitheliomatous hyperplasia. All these cases were positive for AE1/AE3 and pseudoepitheliomatous hyperplasia displayed a strong basal and parabasal reaction against podoplanin. The podoplanin expression in pseudoepitheliomatous hyperplasia in BRONJ specimens should not be considered a sign of malignancy. We discuss the current and possible future roles of surgical pathologists in diagnosing morphological changes associated with the development and therapy of BRONJ lesions.
影响因子：
45.3
作者：
Kawaguchi, Hidetoshi;El-Naggar, Adel K.;Mao, Li
通讯作者：
Mao, Li