Optical coherence tomography monitoring for laser surgery of laryngeal carcinoma
Optical coherence tomography monitoring for laser surgery of laryngeal carcinoma
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DOI：
10.1002/jso.1105
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发表时间：
2001-08-01
影响因子：
2.5
通讯作者：
Sergeev, AM
中科院分区：
文献类型：
--
作者：
Shakhov, AV;Terentjeva, AB;Sergeev, AM
背景和目的：本研究的目的是应用一种新的生物成像模式，光学相干断层扫描（OCT），术中控制在激光手术的喉癌。研究设计/材料和方法：我们研究了26例喉癌原位和在T-1，T-2阶段。我们使用内窥镜OCT设备在0.83 μ m的波长下成像，单个（200 × 200像素）断层图像的采集速率约为0.5帧/秒。所有患者手术YAG：Nd激光在两个可切换的波长为1.44妈妈和1.32妈妈喉裂，直接显微喉镜，纤维喉镜。结果：信息结构变化在喉粘膜的z深度为2毫米，通过OCT获得，可以精确定位肿瘤的边界，从而提供了一个机会，以控制喉癌的手术治疗。波长为1.32 tm和1.44 tm的YAG：Nd激光手术刀在开喉和闭喉手术中均获得成功，这是因为其具有有效的凝固和最小化的侧支组织损伤面积。结论：OCT有望成为喉癌诊断的一种新方法和激光治疗监测的一种工具。外科肿瘤学杂志2001;77：253-258。(C)2001 Wiley-Liss，Inc.
Background and Objective: The goal of this study is to apply a new bioimaging modality, the Optical Coherence Tomography (OCT), for intraoperative control in laser surgery of laryngeal carcinoma.Study Design/Materials and Methods: We studied 26 patients with laryngeal carcinoma in situ and in T-1, T-2 stage. We used an endoscopic OCT device for imaging at a wavelength of 0.83 mum with the acquisition rate of approximately 0.5 frames/s for a single (200 x 200 pixel) tomogram. All patients were operated with a surgical YAG:Nd laser at two switchable wavelengths of 1.44 mum and 1.32 mum by laryngofissure, direct microlaryngoscopy, and fibrolaryngoscopy.Results: Information on structural alterations in laryngeal mucosa to the z depth of 2 mm, obtained by OCT, makes it possible to precisely locate tumor borders, thus giving an opportunity to control the surgical treatment of laryngeal carcinoma. The YAG:Nd laser scalpel with wavelengths of 1.32 tm and 1.44 tm is successful in surgical procedures both in open and closed larynx due to efficient coagulation and minimization of collateral tissue damage area. Combination of the two wavelengths in the single laser unit and intraoperative OCT monitoring result is a new modality for minimally invasive larynx surgery.Conclusions: OCT is promising to become a new diagnosing method of laryngeal carcinoma and a tool for laser treatment monitoring. J. Surg. Oncol. 2001;77:253-258. (C) 2001 Wiley-Liss, Inc.