Harsh parent-child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma
Harsh parent-child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma
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DOI：
10.1017/s0954579415000930
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Chen, Edith
中科院分区：
文献类型：
--
作者：
Ehrlich, Katherine B.;Miller, Gregory E.;Chen, Edith
哮喘是一种慢性呼吸系统疾病，影响着美国超过 700 万儿童。有证据表明，家庭压力源与哮喘症状恶化有关，一些研究表明，这些压力经历会导致儿童免疫系统发生变化，从而加剧气道炎症并导致急性和慢性哮喘症状。我们研究了观察到的亲子冲突经历与参与调节气道炎症和阻塞的抗炎信号转导的信号分子表达之间的关联。 57 名儿童及其父母参与了一项冲突任务，编码员对互动进行评分，以找出严厉和支持行为的证据。孩子们报告了他们对父母支持的看法，并报告了两周内每天的哮喘症状。我们收集了儿童的外周血来测量白细胞中糖皮质激素受体和 β2-肾上腺素能受体信使 RNA 的表达。分析显示，激烈的冲突行为与信使 RNA 表达减少和更严重的哮喘症状有关。支持行为和感知到的父母支持均与基因表达或哮喘症状无关。这些发现表明，与父母的严厉互动与关键抗炎信号分子的下调和哮喘儿童的呼吸困难有关。患有哮喘的儿童也是虐待的受害者，可能特别容易受到免疫细胞转录变化的影响，随着时间的推移，这些变化可能会使哮喘恶化。
Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent-child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the beta 2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time.