Skeletal effects of zinc deficiency in growing rats
Skeletal effects of zinc deficiency in growing rats
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DOI：
10.1016/s0946-672x(99)80019-4
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发表时间：
1999-07-01
影响因子：
3.5
通讯作者：
Roth, HP
中科院分区：
文献类型：
--
作者：
Eberle, J;Schmidmayer, S;Roth, HP
有充分的证据表明，锌在骨代谢中发挥着重要作用，锌缺乏被认为是骨质疏松症发生的危险因素。本研究的目的是利用定量骨组织形态计量学研究营养锌缺乏对生长中大鼠骨骼的影响。将平均初始体重为 101 +/- 2 g 的 24 只雄性 Sprague Dawley 大鼠分为两组，每组 12 只，并可以自由食用半合成、基于酪蛋白的缺锌饮食（0.76 mg 锌/kg）或添加每公斤 60 mg 锌的相同饮食。实验开始42天后处死所有大鼠，并取出右侧股骨远端进行骨组织形态测定。相对于对照组（+Zn），缺锌大鼠（-Zn）的体重显着降低，血浆和股骨锌浓度降低约 80%。股骨远端干骺端的组织形态学评估表明，缺锌导致股骨干骺端减少 45%（p
There is ample evidence that zinc plays an important role in bone metabolism and zinc deficiency has been implicated as a risk factor in the development of osteoporosis. It was the aim of the present study to investigate the skeletal effects of alimentary zinc deficiency in growing rats using quantitative bone histomorphometry. Twenty-four male Sprague Dawley rats with a mean initial body weight of 101 +/- 2 g were allocated in two groups of 12 rats each and had free access to a semi-synthetic, casein-based, zinc-deficient diet (0.76 mg zinc/kg) or to the same diet supplemented with 60 mg zinc per kg. All rats were sacrificed 42 days after the start of the experiment and the right distal femur was removed for bone histomorphometry. Relative to controls (+Zn), the zinc-deficient rats (-Zn) had a significantly lower body weight and about an 80% reduction in plasma and femur zinc concentration. The histomorphometric evaluation of the distal femoral metaphysis showed that zinc deficiency led to a 45% reduction (p