Elastic fibres.
Elastic fibres.
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DOI：
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发表时间：
2002
影响因子：
4
通讯作者：
C. Kielty;M. Sherratt;C. Shuttleworth
中科院分区：
文献类型：
--
作者：
C. Kielty;M. Sherratt;C. Shuttleworth
弹性纤维是必需的细胞外基质大分子，其包含被富含原纤维蛋白的微纤维的套包围的弹性蛋白核心。它们赋予血管、肺和皮肤等结缔组织弹性和恢复力的关键特性。弹性纤维的生物学是复杂的，因为它们具有多个组件，严格调节的发育沉积，多步骤的分级组装和独特的生物力学功能。然而，它们的分子复杂性终于被在识别组分分子之间的相互作用、超微结构分析和信息小鼠模型研究方面的进展所解开。
Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as blood vessels, lungs and skin with the critical properties of elasticity and resilience. The biology of elastic fibres is complex because they have multiple components, a tightly regulated developmental deposition, a multi-step hierarchical assembly and unique biomechanical functions. However, their molecular complexity is at last being unravelled by progress in identifying interactions between component molecules, ultrastructural analyses and studies of informative mouse models.