Intensity-Modulated Radiotherapy Triggers Onset of Bullous Pemphigoid in a Patient with Advanced Melanoma Treated with Nivolumab.
Intensity-Modulated Radiotherapy Triggers Onset of Bullous Pemphigoid in a Patient with Advanced Melanoma Treated with Nivolumab.
复制标题
调强放疗引发接受纳武单抗治疗的晚期黑色素瘤患者出现大疱性类天疱疮。
DOI：
10.1159/000487127
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发表时间：
2018-01
影响因子：
0.8
通讯作者：
Aiba S
中科院分区：
文献类型：
--
作者：
Tanita K;Fujimura T;Kambayashi Y;Tsukada A;Sato Y;Hashimoto A;Aiba S
由于伊匹单抗对耐尼鲁单抗的晚期黑色素瘤的疗效极低，因此需要针对抗PD-1抗体治疗耐药的晚期黑色素瘤的额外支持性治疗。尽管已经报道了几种增强抗PD-1抗体抗肿瘤免疫应答的支持疗法，但同时检测到了非预期的免疫相关不良事件。在这份报告中，我们描述了一名晚期黑色素瘤患者接受纳武利尤单抗治疗，随后接受调强放疗，这可能引发了大疱性类天疱疮（BP）。虽然已经报道了在抗PD-1抗体治疗的患者中发生BP的几个病例，但在本报告中，我们揭示了在通过M2巨噬细胞接受纳武单抗治疗的患者中发生BP的可能发病机制。
Since the efficacy of ipilimumab on nivolumab-resistant advanced melanoma is extremely low, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma is needed. Although several supportive therapies that enhance the antitumor immune response of anti-PD-1 antibodies have already been reported, unexpected immune-related adverse events were detected at the same time. In this report, we describe a patient with advanced melanoma treated with nivolumab followed by intensity-modulated radiotherapy, which might have triggered bullous pemphigoid (BP). Although several cases of BP developing in anti-PD-1 antibody-treated patients have already been reported, in this report, we shed light on the possible pathogenesis of BP developing in a patient treated with nivolumab through M2 macrophages.