Biological effect of shock waves on rat brain: pathological evaluation by compact Ho:YAG-laser-induced cavitational shock wave generator
Biological effect of shock waves on rat brain: pathological evaluation by compact Ho:YAG-laser-induced cavitational shock wave generator
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冲击波对大鼠脑的生物学效应：紧凑型 Ho:YAG 激光诱导空化冲击波发生器的病理评估
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Yoshimoto
中科院分区：
文献类型：
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作者：
A. Nakagawa;T. Hirano;Y. Kusaka;Motoyuki Sato;R. Shirane;K. Takayama;T. Yoshimoto
为介绍冲击波作为一种新的治疗脑、颅骨附近病变的方法，研究了冲击波暴露后压力依赖性脑损伤。本文介绍了一种新型的钬激光空化冲击波发生器（直径15 mm，重量20 g）。在第一部分中，我们利用高速摄影、阴影摄影、压力量测等方法，发展并研究了本发电机的特性。用Ho：YAG激光照射内供水的黄铜管，观察到局部冲击波的产生，而激光没有产生有害的影响。乳胶膜与丙烯酸水容器的放置后，减轻了伴随的激光诱导液体射流的机械效应。放置隔膜前，产生的冲击波的最大超压为15 MPa，放置隔膜后为5 MPa。第二部分研究了5只雄性SD大鼠的冲击波脑损伤。虽然在1 - 5 MPa之间可以观察到蛛网膜下腔出血，但在5 MPa以上也可以观察到脑内出血和组织撕裂。因此，暴露冲击波在脑表面的超压应控制在1 MPa以下。
To introduce shock wave as a new treatment modality for the lesions in the vicinity of brain and skull, pressure-dependent brain damages after exposure of shock wave were investigated. A novel compact Ho:YAG laser-induced cavitational shock wave generator (diameter: 15 mm, weight: 20g) was used intstead of clinical lithotriptors due to their wide distribution of shock waves. In the first part, we have developed and investigated characteristics of present generator by means of high-speed photography, shadowgraphy, and pressure measurement. Generation of localized shock wave without harmful effect of laser was observed after irradiation of Ho:YAG laser in the brass tube with internal water supply. Mechanical effect of accompanying laser-induced liquid jet was mitigated after placement of latex diaphragm with acrylic water reservoir. Maximum overpressure of generated shock wave was 15 MPa before placement of diaphragm, and 5 MPa after placement of diaphragm. In the second part, shock wave-induced brain damages were investigated in 5 male Sprague-Dawley rats. While subarachnoid hemorrhage could be observed between 1 and 5 MPa, intracerebral hemorrhage, and laceration of tissue were also observed above 5 MPa. We therefore conclude that overpressure of exposing shock wave over brain surface should be managed under 1 MPa.
影响因子：
2.9
作者：
Zhong, P;Zhou, YF;Zhu, SL
通讯作者：
Zhu, SL