Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function
Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function
复制标题
DOI：
10.1086/320996
复制
发表时间：
2001-07-01
影响因子：
6.4
通讯作者：
Holt, PG
中科院分区：
文献类型：
--
作者：
Rowe, J;Macaubas, C;Holt, PG
在婴儿期，对疫苗的细胞免疫是高度可变的。这项研究提出了这样一个假设，即这些反应是由适应性免疫能力的成熟变化的速度决定的，特别是，细胞功能是出生后从Th 2向Th 1“偏倚过渡的基础。“在2、4、6、12和18个月的婴儿中收集的外周血单核细胞中追踪破伤风特异性细胞因子反应。这些与多克隆反应进行了比较。结果表明，疫苗应答的Th 2组分迅速发展并保持稳定，不像干扰素（IFN）-γ的产生，其也是早期启动的，但通常在6个月的最终引发剂量后下降。然而，在12至18个月之间，疫苗特异性应答的IFN-γ组分自发复苏，与总体IFN-γ生产能力的平行增加相一致。疫苗特异性应答的Th 2组分在有特应性家族史的儿童中更为突出。
Cellular immunity to vaccines is highly variable during infancy. This study addressed the hypothesis that these responses are governed by the pace of maturational changes in adaptive immune competence, in particular, cellular functions that underlie the postnatal transition from Th2 to Th1 "bias." Tetanus-specific cytokine responses were tracked in peripheral blood mononuclear cells collected from infants at months 2, 4, 6, 12, and 18. These were compared with polyclonal responses. Results show that the Th2 component of the vaccine response develops rapidly and remains stable, unlike interferon (IFN)-gamma production, which also is initiated early but commonly declines after the final priming dose at 6 months. However, between 12 and 18 months, the IFN-gamma component of the vaccine-specific response has a spontaneous resurgence that coincides with a parallel increase in overall IFN-gamma production capacity. The Th2 component of vaccine-specific responses was more prominent in children with atopic family history.