Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129
Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129
复制标题
DOI：
10.1073/pnas.1011912107
复制
发表时间：
2010-12-14
影响因子：
11.1
通讯作者：
Ruppert, Kai
中科院分区：
文献类型：
--
作者：
Mugler, John P., III;Altes, Talissa A.;Ruppert, Kai
尽管医学成像技术取得了无数的进步，并且越来越需要解决哮喘和慢性阻塞性肺病等肺部疾病对健康和生活质量的全球影响，但以适合人类常规应用的方式获得肺气体输送到空域以及肺实质和血液吸收气体的最基本生理功能的体内区域描述和量化仍然具有挑战性。我们报告了一种基于超极化氙 129 MRI 的方法，该方法允许同时观察通气（气体输送）和气体摄取的 3D 分布，以及基于相关通气的区域气体摄取的量化。患有肺部疾病的受试者表现出与许多区域通气时不同的气体摄取变化，这表明通过该技术测量的气体摄取反映了肺组织或局部血流的潜在病理改变等特征。此外，与健康受试者相比，患有肺病的受试者中与气体摄取相关的信号与与通气相关的信号的比率显着改变。这种基于 MRI 的方法提供了一种量化气体输送、交换和运输之间关系的方法，并且似乎具有提供对肺部疾病更多了解的巨大潜力。
Despite a myriad of technical advances in medical imaging, as well as the growing need to address the global impact of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease, on health and quality of life, it remains challenging to obtain in vivo regional depiction and quantification of the most basic physiological functions of the lung-gas delivery to the airspaces and gas uptake by the lung parenchyma and blood-in a manner suitable for routine application in humans. We report a method based on MRI of hyperpolarized xenon-129 that permits simultaneous observation of the 3D distributions of ventilation (gas delivery) and gas uptake, as well as quantification of regional gas uptake based on the associated ventilation. Subjects with lung disease showed variations in gas uptake that differed from those in ventilation in many regions, suggesting that gas uptake as measured by this technique reflects such features as underlying pathological alterations of lung tissue or of local blood flow. Furthermore, the ratio of the signal associated with gas uptake to that associated with ventilation was substantially altered in subjects with lung disease compared with healthy subjects. This MRI-based method provides a way to quantify relationships among gas delivery, exchange, and transport, and appears to have significant potential to provide more insight into lung disease.