Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension
Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension
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DOI：
10.1136/bjo.85.7.792
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发表时间：
2001-07-01
影响因子：
4.1
通讯作者：
Mojon, DS
中科院分区：
文献类型：
--
作者：
Ventura, ACS;Böhnke, M;Mojon, DS
背景/目的-最近的研究表明，高眼压患者的中央角膜比正常人厚，而正常眼压青光眼患者的中央角膜比正常人薄，这是通过超声角膜厚度测量确定的。由于角膜厚度测量和压平眼压计估计的眼内压（IOP）呈正相关，监测前一个参数已作为调整读数的基础，后者，其结果是，许多患者不得不重新分类。为了验证这些角膜厚度测量研究，使用光学低相干反射测量法（optical low coherence reflectometry）确定了正常眼压性青光眼、原发性开角型青光眼、假性剥脱性青光眼或高眼压症患者以及正常受试者的中央角膜厚度，光学低相干反射测量法是一种比超声角膜厚度测量法更精确的新方法。20例原发性开角型青光眼，13例假性剥脱性青光眼，12例高眼压症，以及21例对照受试者被纳入这项观察性、同期病例对照研究。随机选择每个个体的一只眼睛进行研究。眼压测量Goldmann压平眼压计和中央角膜厚度的光学低相干reflectometer.Results-Central角膜厚度显着较高（p小于或等于0.001），在高眼压患者比正常人或受试者与正常眼压性青光眼，原发性开角型青光眼，或假性剥脱性青光眼，有没有后四组之间的显着差异。高眼压患者也显着年轻（p小于或等于0.003）比内的任何三个青光眼groups.Conclusion-This研究证实，一个显着数量的高眼压患者有正常的IOP后，适当的调整，从正常的中央角膜厚度的偏差。后一个参数的准确测量不仅对于个体患者护理（允许更精确地估计IOP），而且对于临床研究（确保更可靠的受试者分类）都很重要。
Background/aims-Recent studies have revealed patients with ocular hypertension to have thicker than normal central corneas and those with normal tension glaucoma to have thinner than normal ones, as determined by ultrasonic pachymetry. Since corneal thickness measurements and applanation tonometric estimates of intraocular pressure (IOP) correlate positively, monitoring of the former parameter have served as the basis for adjusting readings pertaining to the latter, with the consequence that many patients have had to be reclassified. With a view to validating these pachymetric studies, the central corneal thickness was determined in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension, as well as that of normal subjects, using optical low coherence reflectometry, which is a new and more precise method than ultrasonic pachymetry.Methods-34 patients with normal tension glaucoma, 20 with primary open angle glaucoma, 13 with pseudoexfoliation glaucoma, and 12 with ocular hypertension, together with 21 control subjects, were included in this observational, concurrent case-control study. One eye per individual was randomly selected for investigation. IOP was measured by Goldmann applanation tonometry and central corneal thickness by optical low coherence reflectometry.Results-Central corneal thickness was significantly higher (p less than or equal to0.001) in patients with ocular hypertension than in normal individuals or in subjects with either normal tension glaucoma, primary open angle glaucoma, or pseudoexfoliation glaucoma, there being no significant differences between the latter four groups. Patients with ocular hypertension were also significantly younger (p less than or equal to0.003) than those within any of the three glaucomatous groups.Conclusion-This study confirms that a significant number of patients with ocular hypertension have normal IOPs after the appropriate adjustments have been made for deviations from normal in their central corneal thickness. The accurate measurement of this latter parameter is important not only for individual patient care, in permitting more precise estimations of IOP, but also for clinical studies, in assuring a more reliable classification of subjects.