Effect of intravenous contrast on treatment planning system dose calculations in the lung?
Effect of intravenous contrast on treatment planning system dose calculations in the lung?
复制标题
静脉注射造影剂对肺部治疗计划系统剂量计算的影响？
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
D. Forstner
中科院分区：
文献类型：
--
作者：
J. Lees;L. Holloway;M. Fuller;D. Forstner
静脉内对比增强计算机断层扫描用于放射治疗肺治疗计划，以改善肿瘤体积和淋巴结区域的描绘。在所得到的CT图像中，肺的血管结构内的电子密度增加，并且肺体积中的总密度也可能增加。到目前为止，尚不清楚密度的变化是否会影响基于该CT数据的剂量计算的准确性。进行了两项调查。首先，使用拟人体模模拟对比度增强。在第二项研究中，在现有患者数据集中进行了体积密度校正。在这两项研究中，使用造影前和造影后数据集生成治疗计划。比较了每个计划中计算的监测单元数，以及由此产生的等剂量曲线、剂量体积直方图和物理平均肺剂量。从对比度和非对比度增强数据集计算的监视器单元数量在2%范围内一致。等剂量曲线和剂量体积直方图在大小和形状上显示出非常小的差异。随着造影剂的引入，计算的物理平均肺剂量仍低于可接受计划的推荐限值。这些结果表明，造影剂的引入对肺癌治疗计划的剂量影响最小。
Intravenous contrast-enhanced computed tomography is utilised in radiotherapy lung treatment planning to improve the delineation of the tumour volume and nodal areas. In the resultant CT images, the electron density is increased within the vascular structures of the lung and the overall density in the lung volume may also be increased. As yet, it is unclear whether the change in density affects the accuracy of dose calculations based on this CT data. Two investigations were undertaken. Firstly, contrast-enhancement was simulated using an anthropomorphic phantom. In the second investigation, bulk density corrections were performed in an existing patient dataset. In both investigations, treatment plans were generated using both pre- and post-contrast datasets. The numbers of monitor units calculated in each of the plans were compared, as were the resulting isodose curves, dose volume histograms and physical mean lung doses. The numbers of monitor units calculated from the contrast- and non contrast-enhanced datasets agreed within 2%. The isodose curves and dose volume histograms showed very minor differences in size and shape. With the introduction of contrast agent, the physical mean lung doses calculated remained below the limit recommended for an acceptable plan. These results indicate that the introduction of contrast agent has a minimal dosimetric impact upon lung cancer treatment plans.
DOI：
10.1016/s0360-3016(01)01685-6
发表时间：
2001-11-01
影响因子：
7
作者：
Hernando, ML;Marks, LB;Lind, PA
通讯作者：
Lind, PA