SPECIES-SPECIFIC EXPRESSION OF SIALOSYL-LE(X) ON POLYMORPHONUCLEAR LEUKOCYTES (PMN), IN RELATION TO SELECTIN-DEPENDENT PMN RESPONSES
SPECIES-SPECIFIC EXPRESSION OF SIALOSYL-LE(X) ON POLYMORPHONUCLEAR LEUKOCYTES (PMN), IN RELATION TO SELECTIN-DEPENDENT PMN RESPONSES
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DOI：
10.1007/bf00731223
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发表时间：
1994-06-01
影响因子：
3
通讯作者：
HAKOMORI, SI
中科院分区：
文献类型：
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作者：
ITO, K;HANDA, K;HAKOMORI, SI
唾液酰基- le (x) （SLe(x)）及其位置异构体唾液酰基- le (a)是E-和p -选择的凝集素结构域识别的表位。SLe(x)在多形核白细胞（PMN）中的表达通过激活选择素在炎症部位募集这些细胞中发挥重要作用。我们研究了SLe(x)在七种哺乳动物PMN中的表达，并与人类进行了比较。只有人类的PMN（没有其他物种）表达SLe(x)或其他乳酸系列表位，如Le(x)或Le(y)。在大鼠PMN中观察到的这些表位的缺失似乎与最近的报道不一致，报道称大鼠模型中的肺部炎症过程被SLe(x)低聚糖灌注抑制(Mulligan MS, et al. (1993a) Nature 364:149；（1993b）中华医学杂志[J]:623。大鼠的选择可能能够识别SLe(x)，即使在大鼠PMN中缺乏这个表位。
Sialosyl-Le(x) (SLe(x)) and its positional isomer sialosyl-Le(a) are the epitopes recognized by the lectin domain of E- and P-selectins. Expression of SLe(x) in polymorphonuclear leukocytes (PMN) plays an important role in recruitment of these cells at sites of inflammation through activation of selectins. We studied expression of SLe(x) in PMN of seven mammalian species in comparison with that in humans. Only PMN of humans (no other species) expressed SLe(x) or other lacto-series epitopes such as Le(x) or Le(y). The observed absence of these epitopes in rat PMN seems inconsistent with recent reports that the lung inflammation process in a rat model is inhibited by perfusion of SLe(x) oligosaccharide (Mulligan MS, et al. (1993a) Nature 364:149; (1993b) J Exp Med 178:623). Rat selectins may be able to recognize SLe(x), even though this epitope is absent in rat PMN.