Evolutionary Theory of Cancer
Evolutionary Theory of Cancer
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DOI：
10.1111/j.1749-6632.2009.04880.x
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Michor, Franziska
中科院分区：
文献类型：
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作者：
Attolini, Camille Stephan-Otto;Michor, Franziska
正如西奥多西·多布赞斯基（Theodosius Dobzhansky）在1973年所指出的，“生物学中没有任何东西是有意义的，除非从进化的角度出发”，癌症也不例外。通过将癌症视为进化过程的产物，我们对癌症的发生、发展、治疗和耐药性的理解已经有了很大的进步。在这里，我们回顾了癌症进化的数学模型的文献，并提供了一个综合和讨论的领域。
As Theodosius Dobzhansky famously noted in 1973, "Nothing in biology makes sense except in the light of evolution," and cancer is no exception to this rule. Our understanding of cancer initiation, progression, treatment, and resistance has advanced considerably by regarding cancer as the product of evolutionary processes. Here we review the literature of mathematical models of cancer evolution and provide a synthesis and discussion of the field.