Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001
Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001
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1976 年至 2001 年日本东京 A 基因型乙型肝炎病毒感染情况
DOI：
10.1007/s00535-004-1400-3
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发表时间：
2004
影响因子：
6.3
通讯作者：
H. Kumada
中科院分区：
文献类型：
--
作者：
M. Kobayashi;F. Suzuki;Y. Arase;N. Akuta;Yoshiyuki Suzuki;T. Hosaka;S. Saitoh;M. Kobayashi;A. Tsubota;T. Someya;K. Ikeda;M. Matsuda;J. Sato;H. Kumada
背景由于乙型肝炎病毒 (HBV) 基因型 A 不是本土的，因此在日本感染该病毒的数据很少。 方法我们对 1976 年至 2001 年间在日本东京虎之门医院住院的 66 名被发现患有 HBV/A 感染的日本患者进行了临床和病毒学特征检查。通过对preS1和preS2区域以及S基因序列进行系统发育分析，将A型HBV分为A亚型（欧洲型）和A'亚型（南非型）。 结果 66例HBV/A感染患者中，无症状携带者14例（21%），急性肝炎26例（39%），慢性肝炎22例（33%），4例。 (6%)患有肝硬化。 26 名急性肝炎患者中有 5 名 (19%) HBV/A 感染持续超过 6 个月。 1991 年之后，感染 HBV/A 的患者患急性肝炎的频率高于 1991 年之前（2/22 [9%] vs 24/44 [55%]；P < 0.0001）。无症状携带者中 T 核苷酸 1858 的频率高于感染已治愈的急性肝炎患者（5/14 [36%] vs 0/21 [0%]；P = 0.008）。在确定 A 基因型亚型的 57 名患者中，53 名患者 (93%) 被鉴定为 A 亚型，仅 4 名患者 (7%) 被鉴定为 A' 亚型。所有A'亚型感染者均持续感染HBV。结论近年来HBV/A感染日趋频繁，主要表现为急性肝炎，A'亚型在东京都区并不常见。
BackgroundBecause genotype A of hepatitis B virus (HBV) is not indigenous, there have been only few data on infection with it in Japan.MethodsWe examined clinical and virological features of the 66 Japanese patients who admitted Toranomon Hospital in Tokyo, Japan, between 1976 and 2001, who were found to have HBV/A infection. HBV genotype A was classified into subtype A (European type) and A′ (South African type) by phylogenetic analysis of the preS1 and preS2 regions, and the S gene sequences.ResultsOf the 66 patients infected with HBV/A, 14 (21%) were asymptomatic carriers, 26 (39%) presented with acute hepatitis, 22 (33%) with chronic hepatitis, and 4 (6%) with liver cirrhosis. HBV/A infection persisted for more than 6 months in 5 of the 26 (19%) patients with acute hepatitis. The frequency of acute hepatitis in patients infected with HBV/A was higher after than before 1991 (2/22 [9%] vs 24/44 [55%]; P < 0.0001). The frequency of nucleotide 1858 of T was higher in asymptomatic carriers than in patients with acute hepatitis in whom infection was resolved (5/14 [36%] vs 0/21 [0%]; P = 0.008). Of the 57 patients for whom subtypes of genotype A were determined, subtype A was identified in 53 (93%) and subtype A′ in only 4 (7%). All patients infected with subtype A′ were persistently infected with HBV.ConclusionsHBV/A infection has become more frequent during recent years, predominantly presenting as acute hepatitis, and subtype A′ is uncommon in the Tokyo metropolitan area.
影响因子：
29.4
作者：
Chu, CJ;Keeffe, EB;Lok, ASF
通讯作者：
Lok, ASF