The prevalence of Keshan disease in China
The prevalence of Keshan disease in China
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DOI：
10.1016/j.ijcard.2012.11.046
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发表时间：
2013-09-30
影响因子：
3.5
通讯作者：
Wang, Tong
中科院分区：
文献类型：
--
作者：
Li, Qi;Liu, Mingfa;Wang, Tong
背景：克山病哨点监测因无法提供患病率及其估计值而受到限制。为了解全国川崎病患病率和估计患病人数，为制定川崎病防治政策提供依据，采用与人口比例的概率、随机、多阶段、整群抽样的方法，对101,127名儿童进行调查，测定儿童的粮食硒水平，并设计调查问卷调查家庭收入。全国川崎病患病率为2.21%，慢性川崎病患病率为0.50%，潜伏期川崎病患病率为1.71%。慢性川崎病患者主要分布在川崎病流行严重的省份。女性患病率（2.20%）高于男性（1.98%）。这些在年龄较大的群体中也更高。30岁以下病例占13.6%，表明KD仍有发生的可能性。在全国范围内，KD和慢性KD患者的估计数量分别为1，675，500（95% CI，1，608，500 - 1，747，300）和379，800（95% CI，346，700 - 412，800）。多因素Logistic回归分析显示，家庭收入是一个显著的因变量（OR：-0.258，95%CI：-0.332 ~-0.185，p
Background: Sentinel surveillance of Keshan disease (KD) is limited by unable to give the prevalence rates and their estimates. This study was to find the national KD prevalence and the estimated patient numbers to provide evidence toward modifying the policy of KD prevention and control.Method: Using a probability proportional to population size, randomized, multistage, and cluster sampling, we surveyed 101,127, measured grain selenium levels; and surveyed household income with pre-designed questionnaires.Results: The national prevalence rates of KD, chronic KD and latent KD were 2.21%, 0.50%, and 1.71% respectively. Chronic KD patients are mainly in the provinces where KD had been seriously epidemic. The KD prevalence rate was higher in females (2.20%) than in males (1.98%). These were also higher in older age groups. The cases younger than 30 years accounted for 13.6%, indicating the possibility that KD is still occurring. Nationally, the estimated numbers of KD and chronic KD patients are 1,675,500 (95% CI, 1,608,500-1,747,300) and 379,800 (95% CI, 346,700-412,800) respectively. Multiple logistic regression analysis indicated that family income was a significant dependent variable (OR: -0.258, 95% CI: -0.332 to -0.185, p