Bioinspired Fabrication and Evaluation of Molecularly Imprinted Nanocomposite Membranes with Inorganic/Organic Multilevel Structure for the Selective Separation of Emodin
Bioinspired Fabrication and Evaluation of Molecularly Imprinted Nanocomposite Membranes with Inorganic/Organic Multilevel Structure for the Selective Separation of Emodin
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DOI：
10.1142/s1793292019500255
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发表时间：
2019-03
期刊：
影响因子：
1.2
通讯作者：
Chao Yu;Jian Lu;Qi Zhang;Hougang Fan;Minjia Meng;Shi Zhou;Yinhua Jiang;Yongsheng Yan;Yilin Wu;Chunxiang Li
中科院分区：
文献类型：
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作者：
Chao Yu;Jian Lu;Qi Zhang;Hougang Fan;Minjia Meng;Shi Zhou;Yinhua Jiang;Yongsheng Yan;Yilin Wu;Chunxiang Li
随着医疗事业的发展，对高纯度大黄素的需求越来越大。分子印迹膜由于其良好的选择性，在大黄素的选择性分离中得到了广泛的关注。在这项工作中，我们描述了一种在室温下基于有机-无机纳米颗粒（SiO2/TiO2）修饰的醋酸纤维素膜制备大黄素印迹TiO2@CA （ETMIMs）和大黄素印迹SiO2@CA （ESMIMs）的简单两步法。SiO2/TiO2用于提高膜的结构稳定性和粗糙度，多巴胺作为功能单体和交联剂。重要的是，制备的膜不仅表现出增强的再结合能力（[公式：见文]和[公式：见文]），而且具有较好的再结合选择性（物理对ETMIMs和ESMIMs的再结合选择性为2.76和2.99，芦荟大黄素对ETMIMs和ESMIMs的再结合选择性为2.42和3.30）和超选择性（物理对ETMIMs和ESMIMs的再结合选择性为7.59和6.69，芦荟大黄素对ETMIMs和ESMIMs的再结合选择性为5.94和5.78）。经过10个循环步骤后，ETMIMs和ESMIMs的再生能力仍分别保持原有重结合能力的90.4%和89.2%。本研究获得的ETMIMs和ESMIMs在选择性分离纯化大黄素和类似物方面具有潜在的应用前景。
High purity emodin is in great demand with the development of medical treatment. Molecularly imprinted membranes (MIMs) have gained wide attention for selective separation of emodin due to its preferable selectivity. In this work, we describe a simple two-step method for developing emodin-imprinted TiO2@CA (ETMIMs) and emodin-imprinted SiO2@CA (ESMIMs) based on organic–inorganic nanoparticle (SiO2/TiO2) modified cellulose acetate membranes at room temperature. SiO2/TiO2 is used to improve the structural stability and roughness of membranes, and dopamine is used as the functional monomer and crosslinker. Importantly, the as-prepared membranes not only exhibited enhanced rebinding capacity ([Formula: see text] and [Formula: see text]) but also possessed superior rebinding selectivity (2.76 and 2.99 for physcion and 2.42 and 3.30 for aloe emodin onto ETMIMs and ESMIMs) as well as permselectivity (7.59 and 6.69 for physcion and 5.94 and 5.78 for aloe emodin onto ETMIMs and ESMIMs). The regeneration ability of ETMIMs and ESMIMs still maintained 90.4% and 89.2% of the original rebinding capacity after 10 cycling steps, respectively. The ETMIMs and ESMIMs obtained in this work show potential applications for selective separation and purification of emodin from analogs.